metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results
non squamous - mNSCLC - L1 - Wild Type (WT) metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) non squamous cell - mNSCLC - L1 non squamous - mNSCLC - L1 - Wild Type (WT)
versus bevacizumab plus carboplatin and paclitaxel
	atezolizumab plus bevacizumab plus carboplatin plus paclitaxel
	IMpower-150 (ABCP vs BPC WT), 2018 N. Engl. J. Med. 2018; 378:2288-2301 Lancet Respir Med 2019; 7:387-401 J Thorac Oncol. 2021 Jul 24 J Thorac Oncol 2022; 17:309-323-. NCT02366143	RCT	non squamous - mNSCLC - L1 - Wild Type (WT)	atezolizumab plus bevacizumab plus carboplatin plus paclitaxel (ABCP)	bevacizumab and caroplatin plus paclitaxel (BCP)	patients with stage IV or recurrent metastatic nonsquamous NSCLC who had not previously received chemotherapy.	356 / 336	some concern	conclusif	demonstrated 22 % decrease in deaths (OS) (PE) demonstrated 38 % decrease in progression or deaths (PFS) (PE)
	IMpower-150 (ABCP vs BPC ; WT-Teff high), 2018 N. Engl. J. Med. 2018; 378:2288-2301 Lancet Respir Med 2019; 7:387-401 NCT02366143	RCT	non squamous - mNSCLC - L1 - Wild Type (WT)	atezolizumab and bevacizumab, carboplatin plus paclitaxel (ABCP)	bevacizumab plus carboplatin plus paclitaxel (BCP)	patients with stage IV or recurrent metastatic nonsquamous NSCLC who had not previously received chemotherapy.	155 / 129	some concern	conclusif	demonstrated 49 % decrease in progression or deaths (PFS) (PE)
versus carboplatin plus nab-paclitaxel
	atezolizumab plus carboplatin plus nab-paclitaxel
	IMpower-130 (WT), 2019 Lancet Oncol. 2019; 20:924-937 NCT02367781	RCT	non squamous - mNSCLC - L1 - Wild Type (WT)	atezolizumab (ACnP) plus carboplatine plus nab-paclitaxel	carboplatine plus nab-paclitaxel	first-line therapy for patients with stage IV non-squamous nonsmall- cell lung cancer who have not previously received chemotherapy. (EGFRwt and ALKwt)	451 / 228	some concern	conclusif	demonstrated 21 % decrease in deaths (OS) (PE) demonstrated 36 % decrease in progression or deaths (PFS) (PE) statistically significant 1.4-fold increase in DOR
versus pemetrexed plus platin
	atezolizumab plus pemetrexed and platin
	IMpower-132 (WT) unpublished NCT02657434	RCT	non squamous - mNSCLC - L1 - Wild Type (WT)	Atezolizumab (induction and maintenance) plus pemetrexed plus platine	pemetrexed plus platine	Chemotherapy-naive patients with Stage IV non-squamous NSCLC without EGFR or ALK genetic alteration	292 / 286	NA	conclusif	inconclusive 19 % decrease in deaths (OS) (PE) demonstrated 40 % decrease in progression or deaths (PFS) (PE)
	pembrolizumab and pemetrexed plus platin
	KEYNOTE-021, 2016 Lancet Oncol 2016;17:1497-1508 J Thorac Oncol 2019 Jan;14(1):124-129. J Thorac Oncol 2019 Mar;14(3):553-559. J Thorac Oncol 2020 Sep 28;S1556-0864(20)30761-9. NCT02039674	RCT	non squamous - mNSCLC - L1 - Wild Type (WT)	pembrolizumab with carboplatin plus pemetrexed	carboplatin plus pemetrexed	patients with stage IIIB/IV, chemotherapy-naive, nonsquamous non-small-cell lung cancer	60 / 63	some concern	conclusif	demonstrated 47 % decrease in progression or deaths (PFS) (PE) suggested 46 % decrease in PFS (extension) demonstrated 2.1-fold increase in objective responses (ORR) (PE)
versus placebo plus SoC
	pembrolizumab plus SoC
	KEYNOTE-189, 2018 N Engl J Med 2018;378:2078-2092 Lancet Oncol. 2020; 21:387-397 J Med Econ 2018; 21:1191-1205 J Clin Oncol 2020; 38:1505-1517 Lung Cancer 2021 Feb 19;155:53-60. Ann Oncol 2021 Apr 21;S0923-7534(21)01146-7. NCT02578680	RCT	non squamous - mNSCLC - L1 - Wild Type (WT)	pembrolizumab plus pemetrexed plus platine	placebo plus pemetrexed plus platine	participants with advanced or metastatic nonsquamous non-small cell lung cancer who have not previously received systemic therapy for advanced disease	410 / 206	low	conclusif	demonstrated 51 % decrease in deaths (OS) (PE) demonstrated 48 % decrease in progression or deaths (PFS) (PE) suggested 44 % decrease in deaths (OS) (extension) suggested 52 % decrease in PFS (extension) more...

non squamous - mNSCLC - L1 - Wild Type (WT) metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) non squamous cell - mNSCLC - L1 non squamous - mNSCLC - L1 - Wild Type (WT)