metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results
squamous - mNSCLC - L1 - all population metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) squamous cell - mNSCLC - L1 squamous - mNSCLC - L1 - all population
versus carboplatin plus nab-paclitaxel
	atezolizumab plus carboplatin plus nab-paclitaxel
	IMpower-131 (ACnP), 2020 J Thorac Oncol 2020 Aug;15(8):1351-1360. NCT02367794	RCT	squamous - mNSCLC - L1 - all population	atezolizumab plus carboplatine plus nab-paclitaxel(ACnP)	carboplatine plus nab-paclitaxel (CnP)	chemotherapy-naive participants with Stage IV squamous NSCLC	343 / 340	some concern	conclusif	inconclusive 12 % decrease in deaths (OS) (PE) demonstrated 29 % decrease in progression or deaths (PFS) (PE) statistically significant 1.1-fold increase in DOR
versus placebo plus SoC
	pembrolizumab plus SoC
	KEYNOTE-407, 2018 N Engl J Med 2018;379:2040-2051 J. Clin. Oncol. 2020; 38:271-280 NCT02775435	RCT	squamous - mNSCLC - L1 - all population	pembrolizumab plus platine and (nab)paclitaxel	placebo plus platine and (nab)paclitaxel	patients with confirmed stage IV squamous NSCLC who had received no previous systemic therapy for metastatic disease	278 / 281	low	conclusif	demonstrated 36 % decrease in deaths (OS) (PE) demonstrated 44 % decrease in progression or deaths (PFS) (PE)