metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results
non squamous - mNSCLC - L1 - Wild Type (WT) metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) non squamous cell - mNSCLC - L1 non squamous - mNSCLC - L1 - Wild Type (WT)
versus bevacizumab plus carboplatin and paclitaxel
	atezolizumab plus bevacizumab plus carboplatin plus paclitaxel
	IMpower-150 (ABCP vs BPC WT), 2018 N. Engl. J. Med. 2018; 378:2288-2301 Lancet Respir Med 2019; 7:387-401 J Thorac Oncol. 2021 Jul 24 J Thorac Oncol 2022; 17:309-323-. NCT02366143	RCT	non squamous - mNSCLC - L1 - Wild Type (WT)	atezolizumab plus bevacizumab plus carboplatin plus paclitaxel (ABCP)	bevacizumab and caroplatin plus paclitaxel (BCP)	patients with stage IV or recurrent metastatic nonsquamous NSCLC who had not previously received chemotherapy.	356 / 336	some concern	conclusif	demonstrated 22 % decrease in deaths (OS) (PE) demonstrated 38 % decrease in progression or deaths (PFS) (PE)
	IMpower-150 (ABCP vs BPC ; WT-Teff high), 2018 N. Engl. J. Med. 2018; 378:2288-2301 Lancet Respir Med 2019; 7:387-401 NCT02366143	RCT	non squamous - mNSCLC - L1 - Wild Type (WT)	atezolizumab and bevacizumab, carboplatin plus paclitaxel (ABCP)	bevacizumab plus carboplatin plus paclitaxel (BCP)	patients with stage IV or recurrent metastatic nonsquamous NSCLC who had not previously received chemotherapy.	155 / 129	some concern	conclusif	demonstrated 49 % decrease in progression or deaths (PFS) (PE)