interferon - versus control - for COVID-19 severe or critically pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.30 [0.11, 0.83]< 10%1 study (1/-)99.0 %highnot evaluable lowcrucial-
deaths 0.38 [0.21, 0.68]< 10%4 studies (4/-)99.9 %highnot evaluable lowcrucial-
deaths (time to event analysis only) 0.38 [0.16, 0.87]< 10%1 study (1/-)98.8 %highnot evaluable lowcrucial-
clinical improvement 1.53 [0.73, 3.21]> 160%2 studies (2/-)86.9 %highnot evaluable lowimportant-
clinical improvement (time to event analysis only) 1.73 [1.05, 2.86]> 145%4 studies (4/-)98.4 %highnot evaluable lowimportant-
hospital discharge 2.24 [0.99, 5.10]> 10%2 studies (2/-)97.3 %highnot evaluable lowimportant-
mechanical ventilation 0.74 [0.41, 1.34]< 10%4 studies (4/-)84.1 %highnot evaluable lowimportant-
ICU admission 0.49 [0.24, 1.00]< 10%3 studies (3/-)97.4 %some concernnot evaluable moderatenon important-
off oxygenation 8.57 [1.43, 51.36]> 10%1 study (1/-)99.0 %highnot evaluable lownon important-

safety endpoints 00

superinfection 0.77 [0.06, 9.89]< 176%2 studies (2/-)57.8 %highnot evaluable lowimportant-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.