interferon in COVID-19 severe or critically - Summary of results Outcome TE 95% CI n k I2 ROB Pub. bias death D28detailed results Davoudi-Monfared, 2020 0.30 [0.11; 0.83]
Kalil (ACTT-3), 2021 1.74 [0.51; 5.93]
0.70 [0.13 ; 3.86 ] Davoudi-Monfared, 2020, Kalil (ACTT-3), 2021 2 79% 1,050 serious not evaluable deathsdetailed results Darazam (COVIFERON Interferon beta-1a), 2021 0.31 [0.07; 1.25]
Darazam (COVIFERON Interferon beta-1b), 2021 0.52 [0.14; 1.92]
Davoudi-Monfared, 2020 0.38 [0.16; 0.87]
Kalil (ACTT-3), 2021 1.74 [0.51; 5.93]
Rahmani, 2020 0.29 [0.05; 1.56]
0.51 [0.27 ; 0.96 ] Darazam (COVIFERON Interferon beta-1a), 2021, Darazam (COVIFERON Interferon beta-1b), 2021, Davoudi-Monfared, 2020, Kalil (ACTT-3), 2021, Rahmani, 2020 5 24% 1,207 moderate not evaluable deaths (time to event analysis only)detailed results Davoudi-Monfared, 2020 0.38 [0.16; 0.87]
Kalil (ACTT-3), 2021 1.74 [0.51; 5.93]
0.76 [0.17 ; 3.38 ] Davoudi-Monfared, 2020, Kalil (ACTT-3), 2021 2 75% 1,061 serious not evaluable clinical improvementdetailed results Darazam (COVIFERON Interferon beta-1a), 2021 2.36 [1.09; 5.12]
Davoudi-Monfared, 2020 1.10 [0.64; 1.88]
Kalil (ACTT-3), 2021 0.99 [0.87; 1.13]
1.20 [0.80 ; 1.79 ] Darazam (COVIFERON Interferon beta-1a), 2021, Davoudi-Monfared, 2020, Kalil (ACTT-3), 2021 3 58% 1,090 moderate not evaluable clinical improvement (14-day)detailed results Kalil (ACTT-3), 2021 1.01 [0.79; 1.29]
1.01 [0.79 ; 1.29 ] Kalil (ACTT-3), 2021 1 0% 969 NA not evaluable clinical improvement (time to event analysis only)detailed results Darazam (COVIFERON Interferon beta-1a), 2021 2.36 [1.09; 5.12]
Darazam (COVIFERON Interferon beta-1b), 2021 1.42 [0.63; 3.18]
Davoudi-Monfared, 2020 1.10 [0.64; 1.88]
Kalil (ACTT-3), 2021 0.99 [0.87; 1.13]
Rahmani, 2020 3.41 [1.33; 8.73]
1.44 [0.94 ; 2.21 ] Darazam (COVIFERON Interferon beta-1a), 2021, Darazam (COVIFERON Interferon beta-1b), 2021, Davoudi-Monfared, 2020, Kalil (ACTT-3), 2021, Rahmani, 2020 5 65% 1,196 moderate serious hospital dischargedetailed results Davoudi-Monfared, 2020 1.96 [0.76; 5.03]
Rahmani, 2020 3.44 [0.64; 18.49]
2.24 [0.99 ; 5.10 ] Davoudi-Monfared, 2020, Rahmani, 2020 2 0% 147 serious not evaluable mechanical ventilationdetailed results Darazam (COVIFERON Interferon beta-1a), 2021 1.00 [0.27; 3.67]
Darazam (COVIFERON Interferon beta-1b), 2021 1.00 [0.27; 3.67]
Davoudi-Monfared, 2020 0.72 [0.29; 1.76]
Rahmani, 2020 0.29 [0.05; 1.56]
0.74 [0.41 ; 1.34 ] Darazam (COVIFERON Interferon beta-1a), 2021, Darazam (COVIFERON Interferon beta-1b), 2021, Davoudi-Monfared, 2020, Rahmani, 2020 4 0% 227 moderate not evaluable ICU admissiondetailed results Darazam (COVIFERON Interferon beta-1a), 2021 1.00 [0.21; 4.71]
Darazam (COVIFERON Interferon beta-1b), 2021 0.46 [0.11; 1.94]
Rahmani, 2020 0.37 [0.14; 1.00]
0.49 [0.24 ; 1.00 ] Darazam (COVIFERON Interferon beta-1a), 2021, Darazam (COVIFERON Interferon beta-1b), 2021, Rahmani, 2020 3 0% 146 moderate not evaluable off oxygenationdetailed results Davoudi-Monfared, 2020 8.57 [1.43; 51.36]
8.57 [1.43 ; 51.36 ] Davoudi-Monfared, 2020 1 0% 32 NA not evaluable superinfectiondetailed results Davoudi-Monfared, 2020 2.41 [0.75; 7.73]
Rahmani, 2020 0.18 [0.02; 1.59]
0.77 [0.06 ; 9.89 ] Davoudi-Monfared, 2020, Rahmani, 2020 2 76% 147 serious not evaluable 0.2 20.0 1.0 relative treatment effect www.metaEvidence.org 2024-04-20 10:24 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 91
- treatments: 517,881,904,882,897,896,899,1235,898,687,740,883,947
- roots T: 290