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meta|Evidence - COVID-19

Living meta-analysis and evidence synthesis of therapies for COVID19  

Member of the meta|Evidence galaxy

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Treament Trials
Statistically conclusive or suggested result Inconclusive results Uncertain results Safety results
1 noneinconclusive results for: clinical improvement

suggested 30 % decrease in deaths but the degree if certainty is unassessable

suggested 30 % decrease in deaths (time to event analysis only) but the degree if certainty is unassessable

-
11 / 22

statistically conclusive 9 % decrease in deaths

suggested 18 % decrease in mechanical ventilation

inconclusive results for: death D28; death or transfer to ICU; deaths (time to event analysis only); clinical deterioration; clinical improvement; clinical improvement (14-day); clinical improvement (time to event analysis only); death or ventilation; hospital discharge; ICU admission; serious adverse events; superinfection

suggested 4.9-fold increase in radiologic improvement (14-day) but the degree if certainty is unassessable

suggested 78 % increase in viral clearance but the degree if certainty is unassessable

suggested 78 % increase in viral clearance (time to event analysis only) but the degree if certainty is unassessable

-
10

statistically conclusive 30 % increase in clinical improvement

suggested 49 % increase in clinical improvement (14-day)

suggested 45 % increase in clinical improvement (28-day)

suggested 22 % increase in clinical improvement (time to event analysis only)

suggested 33 % decrease in serious adverse events

suggested 42 % decrease in elevated liver enzymes

inconclusive results for: death D28; deaths; deaths (time to event analysis only); clinical deterioration; clinical improvement (7-day); death or ventilation; mechanical ventilation; recovery; AE leading to drug discontinuation; adverse events; deep vein thrombosis; hyperbilirubinemia; pulmonary embolism; renal impairment--
38 / 51

statistically conclusive 13 % decrease in clinical deterioration

inconclusive results for: 14-days deaths; death D28; death or transfer to ICU; deaths; deaths (time to event analysis only); clinical improvement; clinical improvement (14-day); clinical improvement (28-day); clinical improvement (7-day); clinical improvement (time to event analysis only); death or ventilation; hospital discharge; mechanical ventilation; mechanical ventilation (time to event analysis only); viral clearance ; viral clearance by day 14; viral clearance by day 7; ICU admission; off oxygenation; serious adverse events; adverse events--
4 / 7

statistically conclusive 32 % decrease in death D28

statistically conclusive 32 % decrease in deaths

suggested 41 % decrease in deaths (time to event analysis only)

statistically conclusive 24 % increase in clinical improvement

suggested 31 % increase in clinical improvement (14-day)

inconclusive results for: death or transfer to ICU; clinical deterioration; clinical improvement (28-day); death or ventilation; hospital discharge; mechanical ventilation; ICU admission; recovery; acute kidney injury ; arrhythmia; elevated liver enzymes; Myocardial infarction ; venous thromboembolism

statistically conclusive 16 % increase in clinical improvement (time to event analysis only) but the degree if certainty is unassessable

suggested 50 % decrease in superinfection but the degree if certainty is unassessable

-
1 / 2 noneinconclusive results for: deaths--
1 / 2 noneinconclusive results for: death D28; deaths; clinical deterioration

statistically conclusive 37 % decrease in death or ventilation but the degree if certainty is unassessable

-
2

statistically conclusive 25 % decrease in death D28

statistically conclusive 25 % decrease in deaths

suggested 21 % decrease in death or ventilation

suggested 24 % increase in hospital discharge

---
12 / 16

statistically conclusive 66 % increase in clinical improvement (time to event analysis only)

suggested 2.7-fold increase in viral clearance by day 7

inconclusive results for: death D28; deaths; deaths (time to event analysis only); clinical deterioration; clinical improvement; clinical improvement (14-day); death or ventilation; hospital discharge; hospitalization; mechanical ventilation; Recovery (time to event analysis only); viral clearance ; viral clearance (time to event analysis only); viral clearance by day 14; ICU admission; off oxygenation; serious adverse events; superinfection; adverse events

suggested 3.2-fold increase in clinical improvement (28-day) but the degree if certainty is unassessable

suggested 91 % increase in clinical improvement (7-day) but the degree if certainty is unassessable

suggested 2.2-fold increase in recovery but the degree if certainty is unassessable

-
22 / 38

statistically conclusive 26 % increase in clinical improvement

statistically conclusive 17 % decrease in death or ventilation

inconclusive results for: death or transfer to ICU; deaths (time to event analysis only); clinical deterioration; clinical improvement (28-day); clinical improvement (time to event analysis only); hospital discharge; mechanical ventilation; ICU admission; recovery; serious adverse events; superinfection; adverse events-

16 % decrease in death D28 with safety concern

statistically conclusive 15 % decrease in deaths with safety concern
4 / 7 noneinconclusive results for: death D28; deaths; deaths (time to event analysis only); clinical deterioration; clinical improvement; clinical improvement (14-day); clinical improvement (time to event analysis only); death or ventilation; serious adverse events; adverse events--
4 / 5 noneinconclusive results for: deaths; clinical deterioration; clinical improvement; death or ventilation; Major thrombotic events or death; Major bleeding; Thromboembolic events

statistically conclusive 27 % increase in clinical improvement (28-day) but the degree if certainty is unassessable

-
1 noneinconclusive results for: deaths; Major bleeding; Thromboembolic events--

Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant

149
treatments 		  718
studies with results 		  1743
studies screend 		  1629
references

This project is supported by a grant of the French Ministry of Health (Hospital Clinical Research Program, PHRC-N), Université de Lyon (UdL/Idex), and self-funded by Hospices Civils de Lyon, CNRS UMR5558 LBBE University Lyon-1.

     

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