metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results
mNSCLC - L2 - all population metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2) mNSCLC - L2 - all population
versus docetaxel
	atezolizumab alone
	OAK (all population), 2016 Lancet 2017;389:255-265 Clin Lung Cancer 2018; 19:e405-e415 Clin Lung Cancer 2018; 19:441-449.e4 Eur. J. Cancer 2019; 107:124-132 J Thorac Oncol 2018; 13:1156-1170 J Med Econ 2019; 22:625-637 Lung Cancer 2019 Feb;128:105-112. NCT02008227	RCT	mNSCLC - L2 - all population	atelozumab	docetaxel	patients with locally advanced or metastatic (IIIB and IV) non-small cell lung cancer (NSCLC) who have failed platinum therapy	613 / 612	some concern	conclusif	demonstrated 20 % decrease in deaths (OS) (PE)
	POPLAR, 2016 Lancet 2016;387:1837-46 J Immunother Cancer 2019; 7:249 NCT01903993	RCT	mNSCLC - L2 - all population	atezolizumab	docetaxel	patients with locally advanced or metastatic non-small cell lung cancer who have failed platinum therapy	144 / 143	some concern	conclusif	demonstrated 27 % decrease in deaths (OS) (PE)
	avelumab alone
	JAVELIN Lung 200 (all population), 2018 Lancet Oncol. 2018; 19:1468-1479 J Thorac Oncol 2021 Apr 9;S1556-0864(21)01832-3. NCT02395172	RCT	mNSCLC - L2 - all population	avelumab	docetaxel	patients with stage IIIB, IV, or recurrent NSCLC with disease progression after previous platinum doublet treatment	396 / 396	some concern	inconclusive	no statistically significant result
	nivolumab alone
	CheckMate 078, 2019 J Thorac Oncol 2019; 14:867-875 Lung Cancer 2020 Nov 24;152:7-14. Lung Cancer 2021 Dec 27;165:71-81. NCT02613507	RCT	mNSCLC - L2 - all population	nivolumab	docetaxel	Patients with stage IIIB or IV or recurrent squamous or nonsquamous NSCLC progressing during or after one previous platinumbased doublet chemotherapy regimen. (predominantly Chinese patient)	338 / 166	some concern	conclusif	demonstrated 32 % decrease in deaths (OS) (PE) demonstrated 23 % decrease in progression or deaths (PFS) (PE) suggested 25 % decrease in deaths (OS) (extension) suggested 21 % decrease in PFS (extension) more...
	Tislelizumab
	RATIONALE 303 unpublished NCT03358875	RCT	mNSCLC - L2 - all population	Tislelizumab	Docetaxel	Patients With stage IIB or IV Non-Small Cell Lung Cancer Who Have Progressed on a Prior Platinum-Containing Regimen	-/-	NA	no results	no results According to BeiGene, in the interim analysis, the study achieved the primary endpoint of overall survival (OS) in the intent-to-treat (ITT) population