Network meta-analysis for deaths_(OS)

Network meta-analysis estimations pool direct and indirect evidences. These results should be considered as exploratory given the absence of assessment of transitivity assumption plausibility. Calculations by netmeta package.

Evidence network for deaths_(OS)

1KEYNOTE-240, 20201KEYNOTE-394, 2022pembrolizumab alone vs. pembrolizumab based treatment 0.99 [0.71; 1.38]0.99 [0.71;1.38]pembrolizumab alone vs. pembrolizumab based treatment 0.99 [0.71; 1.38]pembrolizumab alone vs. placebo pembrolizumab alone better 0.78 [0.61; 1.00]0.78 [0.61;1.00]pembrolizumab alone vs. placebo pembrolizumab alone better 0.78 [0.61; 1.00]pembrolizumab based treatment vs. pembrolizumab alone 1.01 [0.72; 1.41]1.01 [0.72;1.41]pembrolizumab based treatment vs. pembrolizumab alone 1.01 [0.72; 1.41]pembrolizumab based treatment vs. placebo pembrolizumab based treatment better 0.79 [0.63; 0.99]0.79 [0.63;0.99]pembrolizumab based treatment vs. placebo pembrolizumab based treatment better 0.79 [0.63; 0.99]placebo vs. pembrolizumab alone pembrolizumab alone better 1.28 [1.00; 1.64]1.28 [1.00;1.64]placebo vs. pembrolizumab alone pembrolizumab alone better 1.28 [1.00; 1.64]placebo vs. pembrolizumab based treatment pembrolizumab based treatment better 1.27 [1.01; 1.59]1.27 [1.01;1.59]placebo vs. pembrolizumab based treatment pembrolizumab based treatment better 1.27 [1.01; 1.59]placebopembrolizumab alonepembrolizumab based treatmentdirect evidencenetwork meta-analysis
T vs. C placebopembrolizumab alonepembrolizumab based treatment
placebo---1.28
1.00; 1.64		1.27
1.01; 1.59
pembrolizumab alone0.78
0.61; 1.00		---0.99
0.71; 1.38
pembrolizumab based treatment0.79
0.63; 0.99		1.01
0.72; 1.41		---

pathologies: 133 - treatments: 847,982,359,575,577,576,869,1081,981,875,505,952,1021,1079,767,1071,1074,873,561 result logic

 

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