metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results
non squamous - mNSCLC - L1 - all population metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) non squamous cell - mNSCLC - L1 non squamous - mNSCLC - L1 - all population
versus atezolizumab plus carboplatin plus nab-paclitaxel
	atezolizumab plus carboplatin plus nab-paclitaxel
	IMpower-130 (all population), 2019 Lancet Oncol. 2019; 20:924-937 NCT02367781	RCT	non squamous - mNSCLC - L1 - all population	atezolizumab plus carboplatin plus nab-paclitaxel (ACnp)	carboplatine plus nab-paclitaxel (CnP)	first-line therapy for patients with stage IV non-squamous nonsmall- cell lung cancer and no ALK or EGFR mutations who have not previously received chemotherapy	483 / 240	some concern	conclusif	demonstrated 20 % decrease in deaths (OS) (PE) demonstrated 35 % decrease in progression or deaths (PFS) (PE)
non squamous - mNSCLC - L1 - Wild Type (WT) metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) non squamous cell - mNSCLC - L1 non squamous - mNSCLC - L1 - Wild Type (WT)
versus carboplatin plus nab-paclitaxel
	atezolizumab plus carboplatin plus nab-paclitaxel
	IMpower-130 (WT), 2019 Lancet Oncol. 2019; 20:924-937 NCT02367781	RCT	non squamous - mNSCLC - L1 - Wild Type (WT)	atezolizumab (ACnP) plus carboplatine plus nab-paclitaxel	carboplatine plus nab-paclitaxel	first-line therapy for patients with stage IV non-squamous nonsmall- cell lung cancer who have not previously received chemotherapy. (EGFRwt and ALKwt)	451 / 228	some concern	conclusif	demonstrated 21 % decrease in deaths (OS) (PE) demonstrated 36 % decrease in progression or deaths (PFS) (PE) statistically significant 1.4-fold increase in DOR