metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results
mNSCLC - L1 - PDL1 positive metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) mNSCLC - L1 - PDL1 positive
versus Standard of Care (SoC)
	atezolizumab alone
	IMpower-110 (TC1/2/3 or IC1/2/3), 2020 J Thorac Oncol . 2021 Jul 12;S1556-0864(21)02286-3. NCT02409342	RCT	mNSCLC - L1 - PDL1 positive	atezolizumab	platinium chemotherapy	PD-L1–selected patients (positive for PD-L1 on the SP142 assay) with EGFR and ALK wild-type metastatic NSCLC who had not previously received chemotherapy. (TC 1/2/3)	277 / 277	some concern	inconclusive	inconclusive 17 % decrease in deaths (OS) (PE) suggested 28 % decrease in PFS (extension) suggested 23 % decrease in progression or deaths (PFS)
	IMpower-110 (TC3 or IC3), 2020 NCT02409342	RCT	mNSCLC - L1 - PDL1 positive	atezolizumab	platinum chemotherapy	PD-L1–selected patients (positive for PD-L1 on the SP142 assay) with EGFR and ALK wild-type metastatic NSCLC who had not previously received chemotherapy. (TC 3)	107 / 98	some concern	conclusif	demonstrated 41 % decrease in deaths (OS) (PE) suggested 41 % decrease in PFS (extension) suggested 37 % decrease in progression or deaths (PFS)
	IMpower-110 (TC2/3 or IC2/3), 2020 NCT02409342	RCT	mNSCLC - L1 - PDL1 positive	atezolizumab	platinium chemotherapy	PD-L1–selected patients (positive for PD-L1 on the SP142 assay) with EGFR and ALK wild-type metastatic NSCLC who had not previously received chemotherapy. (TC2/3)	166 / 162	some concern	suggested	suggested 28 % decrease in deaths (OS) (PE) suggested 36 % decrease in PFS (extension) suggested 33 % decrease in progression or deaths (PFS)

mNSCLC - L1 - PDL1 positive metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) mNSCLC - L1 - PDL1 positive

versus Standard of Care (SoC)

atezolizumab alone