metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results
la/mBC - HR-positive - 1st line (L1) breast cancer - HR positive la/mBC - HR positive la/mBC - HR-positive - 1st line (L1)
versus paclitaxel
	capivasertib plus paclitaxel
	BEECH, 2019 Ann Oncol 2019; 30:774-780-. NCT01625286	RCT	la/mBC - HR-positive - 1st line (L1)	capivasertib plus paclitaxel	placebo plus paclitaxel	patients with ER-positive advanced breast cancer with or without a PIK3CA mutation receiving chemotherapy for the first time in the advanced setting	54 / 56	low	inconclusive	inconclusive 20 % decrease in progression or deaths (PFS) (PE)
la/mBC - HR positive - L1 - PIK3CA mutant breast cancer - HR positive la/mBC - HR positive la/mBC - HR-positive - 1st line (L1) la/mBC - HR positive - L1 - PIK3CA mutant
versus paclitaxel
	ipatasertib plus paclitaxel
	IPATunity130, 2022 Breast Cancer Res Treat 2022; 191:565-576-. NCT03337724	RCT	la/mBC - HR positive - L1 - PIK3CA mutant	ipatasertib plus paclitaxel	placebo plus paclitaxel	Patients with HR-positive and HER2-negative PIK3CA/AKT1/PTEN-altered measurable advanced breast cancer	146 / 76	low	inconclusive	inconclusive 0 % increase in progression or deaths (PFS) (PE)