metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results
mNSCLC - L1 - PDL1 negative metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) mNSCLC - L1 - PDL1 negative
versus pemetrexed plus platin
	nivolumab plus SoC
	CheckMate 227 (NC vs C ; PDL1<1%), 2018 N Engl J Med 2018 May 31;378(22):2093-2104. Eur J Cancer 2019 Jul;116:137-147. N Engl J Med 2019 Nov 21;381(21):2020-2031. Oncology (Williston Park) 2020 Jul 15;34(7):254. J Thorac Oncol 2021 Apr;16(4):665-676. NCT02477826	RCT	mNSCLC - L1 - PDL1 negative	nivolumab plus pemetrexed plus platine	platinum based chemotherapy (pemetrexed plus platine)	patients with histologically confirmed squamous or nonsquamous stage IV or recurrent NSCLC who had received no previous systemic anticancer therapy and TMB > 10mut/Mb	177 / 186	some concern	conclusif	demonstrated 27 % decrease in progression or deaths (PFS) (PE)
mNSCLC - L1 - PDL1 positive metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) mNSCLC - L1 - PDL1 positive
versus Standard of Care (SoC)
	nivolumab alone
	CheckMate 026 (PDL1>5%), 2016 N Engl J Med 2017 Jun 22;376(25):2415-2426. NCT02041533	RCT	mNSCLC - L1 - PDL1 positive	Nivolumab	platinum-based chemotherapy	patients previously untreated had histologically confirmed squamous-cell or nonsquamous stage IV or recurrent NSCLC PD-L1 at >1%	211 / 212	some concern	inconclusive	inconclusive 15 % increase in progression or deaths (PFS) (PE)
	CheckMate 026 (PDL1>1%), 2016 N Engl J Med 2017 Jun 22;376(25):2415-2426. NCT02041533	RCT	mNSCLC - L1 - PDL1 positive	Nivolumab	platinium doublet chemotherapy	patients previously untreated had histologically confirmed squamous-cell or nonsquamous stage IV or recurrent NSCLC with PD-L1 >1%	271 / 270	some concern	inconclusive	no statistically significant result

Study

study type

Pathology

Patients

sample sizes

ROB

Results

NCT02477826

RCT

mNSCLC - L1 - PDL1 negative

nivolumab plus pemetrexed plus platine

platinum based chemotherapy (pemetrexed plus platine)

patients with histologically confirmed squamous or nonsquamous stage IV or recurrent NSCLC who had received no previous systemic anticancer therapy and TMB > 10mut/Mb

177 / 186

demonstrated 27 % decrease in progression or deaths (PFS) (PE)

NCT02041533

RCT

mNSCLC - L1 - PDL1 positive

Nivolumab

platinum-based chemotherapy

patients previously untreated had histologically confirmed squamous-cell or nonsquamous stage IV or recurrent NSCLC PD-L1 at >1%

211 / 212

inconclusive 15 % increase in progression or deaths (PFS) (PE)

NCT02041533

RCT

mNSCLC - L1 - PDL1 positive

Nivolumab

platinium doublet chemotherapy

patients previously untreated had histologically confirmed squamous-cell or nonsquamous stage IV or recurrent NSCLC with PD-L1 >1%

271 / 270

mNSCLC - L1 - PDL1 negative metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) mNSCLC - L1 - PDL1 negative

versus pemetrexed plus platin

nivolumab plus SoC

mNSCLC - L1 - PDL1 positive metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) mNSCLC - L1 - PDL1 positive

versus Standard of Care (SoC)

nivolumab alone