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Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) - versus vaccines - for COVID-19 prophylaxis (excluding children) pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

safety endpoints 00

adverse events 1.14 [0.89, 1.46]< 10%2 studies (2/-)14.7 %NAnot evaluable non important-
intracranial hemorrhage 2.24 [0.14, 35.97]< 10%2 studies (2/-)28.6 %NAnot evaluable non important-
ischemic stroke 1.69 [0.13, 22.07]< 10%2 studies (2/-)34.6 %NAnot evaluable non important-
Myocardial infarction 3.74 [0.29, 48.82]< 10%2 studies (2/-)15.9 %NAnot evaluable non important-
pulmonary embolism 2.24 [0.14, 35.97]< 10%2 studies (2/-)28.6 %NAnot evaluable non important-
venous thromboembolism 2.48 [0.08, 74.26]< 10%1 study (1/-)30.3 %NAnot evaluable non important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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