click on circles to display study description...
Vitamin D (n=120) vs. placebo (n=120)
randomized controlled trial
Vitamin D3
Single oral dose of 200,000 IU of vitamin D3 dissolved in a 10-mL peanut oil solution.
Placebo
10 mL of a peanut oil solution.
The solutions were identical in color, taste, smell, consistency, and container.
COVID 19 hospitalized
Age 18 years or older; diagnosis of COVID-19 via PCR testing for SARS-CoV-2 from nasopharyngeal swabs or computed tomography scan findings compatible with the disease (bilateral multifocal ground-glass opacities ≥50%); and diagnosis of flu syndrome with institutional criteria for hospitalization on hospital admission, presenting respiratory rate greater than 24/min, saturation less than 93% while breathing room air, or risk factors for complications (eg, heart disease, diabetes, systemic arterial hypertension, neoplasms, immunosuppression, pulmonary tuberculosis, obesity) followed by COVID-19 confirmation. Patients were excluded if they were already admitted and receiving mechanical ventilation.
Double-blind.
Multicenter: 2 hospitals in Sao Paulo, Brazil.
The criteria used for patient discharge were no need for supplemental oxygen in the past 48 hours, no fever in the past 72 hours, and oxygen saturation greater than 93% without supplemental oxygen and without respiratory distress.
Vitamin D (n=50) vs. standard of care (n=26)
randomized controlled trial
Calcifediol
Day one: 0.532 mg of oral then 0.266 mg on day 3 and 7, and then weekly until discharge or ICU admission.
Standard care
Standard care only
All hospitalized patients received as best available therapy the same standard care, (per hospital protocol), of a combination of hydroxychloroquine (400 mg every 12 h on the first day, and 200 mg every 12 h for the following 5 days), azithromycin (500 mg orally for 5 days.)
COVID 19 hospitalized
open label
Single center: University hospital setting (Reina Sofia University Hospital), Cordoba, Spain.
Outcomes of effectiveness included rate of ICU admission and deaths. The list was accessible only to non-masked specialists in the study in an attempt to minimize observation bias.
vitamin C (n=27) vs. placebo (n=29)
randomized controlled trial
High-dose intravenous Vitamin C
24 g vitamin C per day. Patients were infused with 12 g vitamin C diluted in 50 ml of bacteriostatic water every 12 h at a rate of 12 ml/hour by infusion pump for 7 days.
Placebo
50 ml of bacteriostatic water infused every 12 h at a rate of 12 ml/hour by infusion pump for 7 days.
Patients were randomized to receive vitamin C or placebowithin 48 h after admission to the ICU.
COVID-19 severe or critically
(1) age ≥ 18 and < 80 years; (2) RTPCR positive for SARS-CoV-2; (3) pneumonia confirmed by chest imaging and admission to the ICU; (3) PaO2/ FiO2(P/F) < 300 mmHg.
Double-blind.
Multicenter, 3 hospitals in Hubei, China.
powered by vis.js Network
- About us - Contact us - Method - RSS Made with in Lyon - Credits - Privacy policy -
An extraction panel is open