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leflunomide (n=26) vs. interferon (n=24)
randomized controlled trial
Leflunomide
leflunomide (50 mgevery 12 hours, 3 consecutive times, orally; then 20 mg onc edaily for 8 days; a total course of 10 days) plus nebulized interferon alpha 2a (IFN-α-2a; 3 million IU each time, adding2 mL of sterilized water, atomization inhalation twice daily for10 days)
Interferon alpha 2a
IFN-α-2a, 3 million IU each time, twice daily for 10 days.
COVID 19 all comers
(1) age 18–70 years with a diagnosis of COVID-19 conforming to Chinese guidelines (2) hospitalized for prolonged postsymptomatic viral shedding; (3) able to orally take medication; (4) if female, not pregnant; and (5) effective contraception for 7 days after taking the last medication.
Open-label.
Single center, Renmin Hospital of Wuhan University, Wuhan, China.
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