mRNA vaccine living meta-analysis of clinical studies

demonstrated suggested inconclusive safety concern ongoing study display ongoing demontrated benefit only

	COVID-19 severe or critically

	COVID-19 prophylaxis (excluding children)
mRNA vaccine	Fraiman Nakahara
Comirnaty (tozinameran - Pfizer/BIONTECH)	Kanokudom Haas Watanabe BNT162b2 phase 3 ... xie Lustig
Spikevax (Moderna mRNA-1273 COVID-19 vaccine)	Moderna study 201 100µg COVE Moderna/NIH phase 3 ...

74 studies excluded by filtering options 1

4888	study 101 dose finding, 2020	2	31	0	excluded	not a RCT	risk of bias not avaialble
6486	CoVEHPI (Israel), 0	0	10	0	selection pending
6560	Chodcik, 2021	1	13	3		not a RCT	high risk of bias
6650	Dagan, 2021	1	10	0		not a RCT	risk of bias not avaialble
6663	SIREN (HW england), 2021	1	10	3		not a RCT	high risk of bias
6664	Scotland cohort, 0	1	10	0		not a RCT	risk of bias not avaialble
6668	Amit, 2021	1	10	0		not a RCT	risk of bias not avaialble
6787	Thompson, 2021	1	10	4		not a RCT	high risk of bias
6791	Tande, 0	1	13	0		not a RCT	risk of bias not avaialble
6792	Weekes, 2021	1	13	0		not a RCT	risk of bias not avaialble
6935	Benotmane, 2021	1	32	0		not a RCT	risk of bias not avaialble
6944	Yanay, 2021	1	32	0		not a RCT	risk of bias not avaialble
6949	Pawlowski, 2021	1	13	0		not a RCT	risk of bias not avaialble
6949	Pawlowski, 2021	1	13	0		not a RCT	risk of bias not avaialble
6953	Goldberg, 2021	1	13	0		not a RCT	risk of bias not avaialble
6961	Zadok, 2021	1	32	0		not a RCT	risk of bias not avaialble
6965	Bernal (PHE, 19th February 2021), 2021	1	13	0		not a RCT	risk of bias not avaialble
6966	Ou, 2021	2	32	0	excluded	not a RCT	risk of bias not avaialble
6989	Palich, 2021	1	32	0		not a RCT	risk of bias not avaialble
6999	Rozen-Zvi, 2021	1	32	0		not a RCT	risk of bias not avaialble
7001	Boyarsky, 2021	1	32	0		not a RCT	risk of bias not avaialble
7002	Haas, 2021	1	13	0		not a RCT	risk of bias not avaialble
7003	Abu-Raddad, 2021	1	20	0		not a RCT	risk of bias not avaialble
7005	Tang, 2021	1	10	0		not a RCT	risk of bias not avaialble
7006	Angel, 2021	1	13	0		not a RCT	risk of bias not avaialble
7037	Agur, 0	1	10	0		not a RCT	risk of bias not avaialble
7052	Aleman, 2021	1	32	0		not a RCT	risk of bias not avaialble
7100	Chung, 2021	1	20	0		not a RCT	risk of bias not avaialble
8159	Moderna delta VOC press realease, 2021	1	13	0		not a RCT	risk of bias not avaialble
8248	Montgomery, 2021	2	13	0	excluded	not a RCT	risk of bias not avaialble
8270	Heymann, 2021	1	13	0		not a RCT	risk of bias not avaialble
8271	Bjork, 2021	1	13	0		not a RCT	risk of bias not avaialble
8320	Mayo Clinic (Puranik), 2021	1	13	3		not a RCT	high risk of bias
8333	Qatar (Tang), 2021	1	20	3		not a RCT	high risk of bias
8338	Wan, 2021	1	20	4		not a RCT	high risk of bias
8351	Tenforde, 2021	1	20	3		not a RCT	high risk of bias
8352	Nanduri, 2021	1	13	3		not a RCT	high risk of bias
8506	Barda, 2021	1	13	4		not a RCT	high risk of bias
8507	Klein, 2021	1	13	4		not a RCT	high risk of bias
8507	Klein, 2021	1	13	4		not a RCT	high risk of bias
8517	EPI-PHARE, 2021	1	13	4		not a RCT	high risk of bias
9065	Ruddy, 2021	2	32	0	excluded	not a RCT	risk of bias not avaialble
9158	Husby (Moderna), 2021	1	12	0		not a RCT	risk of bias not avaialble
9172	South Africa (Discovery Health, Collie), 2021	1	20	0		not a RCT	risk of bias not avaialble
9203	England (Andrews), 2021	1	20	0		not a RCT	risk of bias not avaialble
9209	Southern California (Tseng) - omicron, 2022	1	20	0		not a RCT	risk of bias not avaialble
9216	Sultan, 2022	0	12	0	selection pending
9218	Coggiola, 2021	0	99	0	selection pending
9293	Tenforde, 2022	1	20	0		not a RCT	risk of bias not avaialble
9316	Shibli, 2021	1	13	0		not a RCT	risk of bias not avaialble
9316	Shibli, 2021	1	13	0		not a RCT	risk of bias not avaialble
9323	Nguyen, 2022	1	10	0		not a RCT	risk of bias not avaialble
9331	McConeghy, 2022	1	10	0		not a RCT	risk of bias not avaialble
9341	EPIPHAR (ARN) DUPLICATE, 2022	0	12	0	selection pending
9346	Simpson (Comirnaty), 2021	0	12	0	selection pending
9359	Husby (pfizer), 2021	1	12	0		not a RCT	risk of bias not avaialble
9381	Edward (pfizer), 2021	1	13	4		not a RCT	high risk of bias
9382	Burn (Pfizer), 2021	1	13	4		not a RCT	high risk of bias
9407	Southern California (Tseng) - delta, 2022	1	20	0		not a RCT	risk of bias not avaialble
9409	Thompson -VISIOn Network (omicron), 2022	1	12	0		not a RCT	risk of bias not avaialble
9410	Thompson -VISIOn Network (delta), 2022	0	12	0	selection pending
9411	Accorsi, 2022	1	12	0		not a RCT	risk of bias not avaialble
9415	Patalon, 2022	1	20	0		not a RCT	risk of bias not avaialble
9448	Chalkias, 2022	0	30	0	selection pending
9461	Abu-Raddad, 2022	1	13	0		not a RCT	risk of bias not avaialble
9478	Lauring, 2022	1	20	0		not a RCT	risk of bias not avaialble
9487	Shemer, 2021	1	11	0		not a RCT	risk of bias not avaialble
9487	Shemer, 2021	1	11	0		not a RCT	risk of bias not avaialble
9492	Patone, 2021	1	12	0		not a RCT	risk of bias not avaialble
9584	McMurry, 2021	1	13	0		not a RCT	risk of bias not avaialble
9585	Shasha, 2021	1	12	0		not a RCT	risk of bias not avaialble
9589	Kirsebom (UKHSA), 2022	1	13	0		not a RCT	risk of bias not avaialble
9592	Tartof, 2021	1	13	0		not a RCT	risk of bias not avaialble
9629	Le Vu S. (EPI-PHARE), 2021	0	12	0	selection pending