anti-interleukin-6 living meta-analysis of clinical studies

demonstrated suggested inconclusive safety concern ongoing study display ongoing demontrated benefit only

	COVID 19 hospitalized
	COVID 19 all comers
anti-interleukin-6
sarilumab
sarilumab high dose (400mg)	sarilumab phase 2 high dose
sarilumab low dose (200mg)	sarimulab phase 2 low dose
tocilizumab	BACC Bay Tocilizumab Trial TOCOVID

40 studies excluded by filtering options 1

5123	Gritti et al., 2020	2	30	0	excluded	not a RCT	risk of bias not avaialble
5366	Rimland, 2020	2	30	0	excluded	not a RCT	risk of bias not avaialble
5444	TOCI-RAF Study Group (Campochiaro), 2020	1	13	0		not a RCT	risk of bias not avaialble
5449	Martinez-Sanz, 2020	1	13	4		not a RCT	high risk of bias
5489	Rojas-Marte, 2020	1	13	4		not a RCT	high risk of bias
5494	BREATH-19 Study, 0	2	30	0	excluded	not a RCT	risk of bias not avaialble
5522	Somers, 2020	1	13	4		not a RCT	high risk of bias
5523	Toniati, 2020	2	99	0	excluded	not a RCT	risk of bias not avaialble
5524	HNF Hospital Tocilizumab multidisciplinary team, 2020	1	13	4		not a RCT	high risk of bias
5525	Capra, 2020	1	13	4		not a RCT	high risk of bias
5526	Price, 2020	2	13	0	excluded	not a RCT	risk of bias not avaialble
5527	Colaneri, 2020	1	13	4		not a RCT	high risk of bias
5528	Mathilde, 2020	1	13	4		not a RCT	high risk of bias
5529	Andrew, 2020	1	13	0		not a RCT	risk of bias not avaialble
5554	Tsai, 2020	1	13	3		not a RCT	high risk of bias
5616	Biran, 2020	1	13	3		not a RCT	high risk of bias
5621	Ip, 2020	0	13	4	selection pending
5628	Rossotti, 2020	1	13	4		not a RCT	high risk of bias
5632	Holt, 2020	2	13	0	excluded	not a RCT	risk of bias not avaialble
5633	ARI-RAF (Della-Torre), 2020	1	13	0		not a RCT	risk of bias not avaialble
5672	Klopfenstein, 2020	2	13	4	excluded	not a RCT	high risk of bias
5796	SAM-COVID-19, 2020	0	13	0	selection pending
5805	Mikulska (tocilizumab plus methylprednisolone), 2020	0	13	0	selection pending
5941	Zeng, 2020	0	30	0	selection pending
5965	Pereira, 2020	0	99	0	selection pending
5966	Masia, 2020	0	10	0	selection pending
6281	Roumier, 2020	0	10	0	selection pending
6282	Menzella, 2020	0	13	0	selection pending
6335	Ruiz-Antoran, 2020	0	13	0	selection pending
6414	Mikulska, 2020	0	13	0	selection pending
6418	Guaraldi, 2020	0	13	0	selection pending
6420	Potere, 2020	0	20	0	selection pending
6425	Roumier, 2020	0	13	0	selection pending
6429	Kewan, 2020	0	13	0	selection pending
6431	Moreno-Pérez, 2020	0	13	0	selection pending
6433	Canziani, 2020	0	20	0	selection pending
6435	Gokhale, 2020	0	13	0	selection pending
8509	Karampitsakos, 2021	0	31	0	selection pending
9133	Karakike (ESCAPE), 2021	0	31	0	selection pending
9225	Belhassen-Garc??a, 2021	0	11	0	selection pending