Network meta-analysis for deaths_(OS)

Network meta-analysis estimations pool direct and indirect evidences. These results should be considered as exploratory given the absence of assessment of transitivity assumption plausibility. Calculations by netmeta package.

Evidence network for deaths_(OS)

2IMmotion-151 (PDL1 >1%), 2019 IMmotion-151 (all population), 20192JAVELIN Renal 101( PDL1>1%), 2019 JAVELIN Renal 101 (all population), 20191KEYNOTE-426, 20193CheckMate 214 (intermediate and poor risk), 2017 CheckMate 214 (favorable risk) EXPLORATORY, 2017 CheckMate 214 (all population), 20171CheckMate 9ER, 20211KEYNOTE-581/CLEAR (PDL1), 20211KEYNOTE-581/CLEAR (mtor), 2021atezolizumab plus bevacizumab vs. avelumab plus axitinib 1.24 [0.99; 1.56]1.24 [0.99;1.56]atezolizumab plus bevacizumab vs. avelumab plus axitinib 1.24 [0.99; 1.56]atezolizumab plus bevacizumab vs. lenvatinib plus everolimus 0.78 [0.57; 1.08]0.78 [0.57;1.08]atezolizumab plus bevacizumab vs. lenvatinib plus everolimus 0.78 [0.57; 1.08]atezolizumab plus bevacizumab vs. nivolumab plus cabozantinib 1.50 [0.97; 2.32]1.50 [0.97;2.32]atezolizumab plus bevacizumab vs. nivolumab plus cabozantinib 1.50 [0.97; 2.32]atezolizumab plus bevacizumab vs. nivolumab plus ipilimumab 1.32 [0.99; 1.76]1.32 [0.99;1.76]atezolizumab plus bevacizumab vs. nivolumab plus ipilimumab 1.32 [0.99; 1.76]atezolizumab plus bevacizumab vs. pembrolizumab plus axitinib pembrolizumab plus axitinib better 1.70 [1.17; 2.47]1.70 [1.17;2.47]atezolizumab plus bevacizumab vs. pembrolizumab plus axitinib pembrolizumab plus axitinib better 1.70 [1.17; 2.47]atezolizumab plus bevacizumab vs. pembrolizumab plus lenvatinib 1.37 [0.97; 1.92]1.37 [0.97;1.92]atezolizumab plus bevacizumab vs. pembrolizumab plus lenvatinib 1.37 [0.97; 1.92]atezolizumab plus bevacizumab vs. sunitinib 0.90 [0.76; 1.07]0.90 [0.76;1.07]atezolizumab plus bevacizumab vs. sunitinib 0.90 [0.76; 1.07]avelumab plus axitinib vs. atezolizumab plus bevacizumab 0.80 [0.64; 1.01]0.80 [0.64;1.01]avelumab plus axitinib vs. atezolizumab plus bevacizumab 0.80 [0.64; 1.01]avelumab plus axitinib vs. lenvatinib plus everolimus avelumab plus axitinib better 0.63 [0.46; 0.86]0.63 [0.46;0.86]avelumab plus axitinib vs. lenvatinib plus everolimus avelumab plus axitinib better 0.63 [0.46; 0.86]avelumab plus axitinib vs. nivolumab plus cabozantinib 1.21 [0.79; 1.85]1.21 [0.79;1.85]avelumab plus axitinib vs. nivolumab plus cabozantinib 1.21 [0.79; 1.85]avelumab plus axitinib vs. nivolumab plus ipilimumab 1.06 [0.80; 1.40]1.06 [0.80;1.40]avelumab plus axitinib vs. nivolumab plus ipilimumab 1.06 [0.80; 1.40]avelumab plus axitinib vs. pembrolizumab plus axitinib 1.37 [0.95; 1.97]1.37 [0.95;1.97]avelumab plus axitinib vs. pembrolizumab plus axitinib 1.37 [0.95; 1.97]avelumab plus axitinib vs. pembrolizumab plus lenvatinib 1.10 [0.79; 1.53]1.10 [0.79;1.53]avelumab plus axitinib vs. pembrolizumab plus lenvatinib 1.10 [0.79; 1.53]avelumab plus axitinib vs. sunitinib avelumab plus axitinib better 0.73 [0.63; 0.84]0.73 [0.63;0.84]avelumab plus axitinib vs. sunitinib avelumab plus axitinib better 0.73 [0.63; 0.84]lenvatinib plus everolimus vs. atezolizumab plus bevacizumab 1.28 [0.93; 1.75]1.28 [0.93;1.75]lenvatinib plus everolimus vs. atezolizumab plus bevacizumab 1.28 [0.93; 1.75]lenvatinib plus everolimus vs. avelumab plus axitinib avelumab plus axitinib better 1.59 [1.17; 2.15]1.59 [1.17;2.15]lenvatinib plus everolimus vs. avelumab plus axitinib avelumab plus axitinib better 1.59 [1.17; 2.15]lenvatinib plus everolimus vs. nivolumab plus cabozantinib nivolumab plus cabozantinib better 1.92 [1.19; 3.10]1.92 [1.19;3.10]lenvatinib plus everolimus vs. nivolumab plus cabozantinib nivolumab plus cabozantinib better 1.92 [1.19; 3.10]lenvatinib plus everolimus vs. nivolumab plus ipilimumab nivolumab plus ipilimumab better 1.68 [1.18; 2.40]1.68 [1.18;2.40]lenvatinib plus everolimus vs. nivolumab plus ipilimumab nivolumab plus ipilimumab better 1.68 [1.18; 2.40]lenvatinib plus everolimus vs. pembrolizumab plus axitinib pembrolizumab plus axitinib better 2.17 [1.42; 3.32]2.17 [1.42;3.32]lenvatinib plus everolimus vs. pembrolizumab plus axitinib pembrolizumab plus axitinib better 2.17 [1.42; 3.32]lenvatinib plus everolimus vs. pembrolizumab plus lenvatinib pembrolizumab plus lenvatinib better 1.74 [1.17; 2.59]1.74 [1.17;2.59]lenvatinib plus everolimus vs. pembrolizumab plus lenvatinib pembrolizumab plus lenvatinib better 1.74 [1.17; 2.59]lenvatinib plus everolimus vs. sunitinib 1.15 [0.88; 1.50]1.15 [0.88;1.50]lenvatinib plus everolimus vs. sunitinib 1.15 [0.88; 1.50]nivolumab plus cabozantinib vs. atezolizumab plus bevacizumab 0.67 [0.43; 1.03]0.67 [0.43;1.03]nivolumab plus cabozantinib vs. atezolizumab plus bevacizumab 0.67 [0.43; 1.03]nivolumab plus cabozantinib vs. avelumab plus axitinib 0.83 [0.54; 1.27]0.83 [0.54;1.27]nivolumab plus cabozantinib vs. avelumab plus axitinib 0.83 [0.54; 1.27]nivolumab plus cabozantinib vs. lenvatinib plus everolimus nivolumab plus cabozantinib better 0.52 [0.32; 0.84]0.52 [0.32;0.84]nivolumab plus cabozantinib vs. lenvatinib plus everolimus nivolumab plus cabozantinib better 0.52 [0.32; 0.84]nivolumab plus cabozantinib vs. nivolumab plus ipilimumab 0.88 [0.55; 1.40]0.88 [0.55;1.40]nivolumab plus cabozantinib vs. nivolumab plus ipilimumab 0.88 [0.55; 1.40]nivolumab plus cabozantinib vs. pembrolizumab plus axitinib 1.13 [0.67; 1.91]1.13 [0.67;1.91]nivolumab plus cabozantinib vs. pembrolizumab plus axitinib 1.13 [0.67; 1.91]nivolumab plus cabozantinib vs. pembrolizumab plus lenvatinib 0.91 [0.55; 1.49]0.91 [0.55;1.49]nivolumab plus cabozantinib vs. pembrolizumab plus lenvatinib 0.91 [0.55; 1.49]nivolumab plus cabozantinib vs. sunitinib nivolumab plus cabozantinib better 0.60 [0.40; 0.89]0.60 [0.40;0.89]nivolumab plus cabozantinib vs. sunitinib nivolumab plus cabozantinib better 0.60 [0.40; 0.89]nivolumab plus ipilimumab vs. atezolizumab plus bevacizumab 0.76 [0.57; 1.01]0.76 [0.57;1.01]nivolumab plus ipilimumab vs. atezolizumab plus bevacizumab 0.76 [0.57; 1.01]nivolumab plus ipilimumab vs. avelumab plus axitinib 0.94 [0.71; 1.24]0.94 [0.71;1.24]nivolumab plus ipilimumab vs. avelumab plus axitinib 0.94 [0.71; 1.24]nivolumab plus ipilimumab vs. lenvatinib plus everolimus nivolumab plus ipilimumab better 0.59 [0.42; 0.85]0.59 [0.42;0.85]nivolumab plus ipilimumab vs. lenvatinib plus everolimus nivolumab plus ipilimumab better 0.59 [0.42; 0.85]nivolumab plus ipilimumab vs. nivolumab plus cabozantinib 1.14 [0.72; 1.81]1.14 [0.72;1.81]nivolumab plus ipilimumab vs. nivolumab plus cabozantinib 1.14 [0.72; 1.81]nivolumab plus ipilimumab vs. pembrolizumab plus axitinib 1.29 [0.86; 1.94]1.29 [0.86;1.94]nivolumab plus ipilimumab vs. pembrolizumab plus axitinib 1.29 [0.86; 1.94]nivolumab plus ipilimumab vs. pembrolizumab plus lenvatinib 1.03 [0.71; 1.51]1.03 [0.71;1.51]nivolumab plus ipilimumab vs. pembrolizumab plus lenvatinib 1.03 [0.71; 1.51]nivolumab plus ipilimumab vs. sunitinib nivolumab plus ipilimumab better 0.68 [0.54; 0.86]0.68 [0.54;0.86]nivolumab plus ipilimumab vs. sunitinib nivolumab plus ipilimumab better 0.68 [0.54; 0.86]pembrolizumab plus axitinib vs. atezolizumab plus bevacizumab pembrolizumab plus axitinib better 0.59 [0.40; 0.85]0.59 [0.40;0.85]pembrolizumab plus axitinib vs. atezolizumab plus bevacizumab pembrolizumab plus axitinib better 0.59 [0.40; 0.85]pembrolizumab plus axitinib vs. avelumab plus axitinib 0.73 [0.51; 1.05]0.73 [0.51;1.05]pembrolizumab plus axitinib vs. avelumab plus axitinib 0.73 [0.51; 1.05]pembrolizumab plus axitinib vs. lenvatinib plus everolimus pembrolizumab plus axitinib better 0.46 [0.30; 0.71]0.46 [0.30;0.71]pembrolizumab plus axitinib vs. lenvatinib plus everolimus pembrolizumab plus axitinib better 0.46 [0.30; 0.71]pembrolizumab plus axitinib vs. nivolumab plus cabozantinib 0.88 [0.52; 1.49]0.88 [0.52;1.49]pembrolizumab plus axitinib vs. nivolumab plus cabozantinib 0.88 [0.52; 1.49]pembrolizumab plus axitinib vs. nivolumab plus ipilimumab 0.78 [0.52; 1.17]0.78 [0.52;1.17]pembrolizumab plus axitinib vs. nivolumab plus ipilimumab 0.78 [0.52; 1.17]pembrolizumab plus axitinib vs. pembrolizumab plus lenvatinib 0.80 [0.52; 1.25]0.80 [0.52;1.25]pembrolizumab plus axitinib vs. pembrolizumab plus lenvatinib 0.80 [0.52; 1.25]pembrolizumab plus axitinib vs. sunitinib pembrolizumab plus axitinib better 0.53 [0.38; 0.74]0.53 [0.38;0.74]pembrolizumab plus axitinib vs. sunitinib pembrolizumab plus axitinib better 0.53 [0.38; 0.74]pembrolizumab plus lenvatinib vs. atezolizumab plus bevacizumab 0.73 [0.52; 1.03]0.73 [0.52;1.03]pembrolizumab plus lenvatinib vs. atezolizumab plus bevacizumab 0.73 [0.52; 1.03]pembrolizumab plus lenvatinib vs. avelumab plus axitinib 0.91 [0.66; 1.26]0.91 [0.66;1.26]pembrolizumab plus lenvatinib vs. avelumab plus axitinib 0.91 [0.66; 1.26]pembrolizumab plus lenvatinib vs. lenvatinib plus everolimus pembrolizumab plus lenvatinib better 0.57 [0.39; 0.85]0.57 [0.39;0.85]pembrolizumab plus lenvatinib vs. lenvatinib plus everolimus pembrolizumab plus lenvatinib better 0.57 [0.39; 0.85]pembrolizumab plus lenvatinib vs. nivolumab plus cabozantinib 1.10 [0.67; 1.81]1.10 [0.67;1.81]pembrolizumab plus lenvatinib vs. nivolumab plus cabozantinib 1.10 [0.67; 1.81]pembrolizumab plus lenvatinib vs. nivolumab plus ipilimumab 0.97 [0.66; 1.41]0.97 [0.66;1.41]pembrolizumab plus lenvatinib vs. nivolumab plus ipilimumab 0.97 [0.66; 1.41]pembrolizumab plus lenvatinib vs. pembrolizumab plus axitinib 1.25 [0.80; 1.94]1.25 [0.80;1.94]pembrolizumab plus lenvatinib vs. pembrolizumab plus axitinib 1.25 [0.80; 1.94]pembrolizumab plus lenvatinib vs. sunitinib pembrolizumab plus lenvatinib better 0.66 [0.49; 0.88]0.66 [0.49;0.88]pembrolizumab plus lenvatinib vs. sunitinib pembrolizumab plus lenvatinib better 0.66 [0.49; 0.88]sunitinib vs. atezolizumab plus bevacizumab 1.11 [0.94; 1.31]1.11 [0.94;1.31]sunitinib vs. atezolizumab plus bevacizumab 1.11 [0.94; 1.31]sunitinib vs. avelumab plus axitinib avelumab plus axitinib better 1.38 [1.19; 1.60]1.38 [1.19;1.60]sunitinib vs. avelumab plus axitinib avelumab plus axitinib better 1.38 [1.19; 1.60]sunitinib vs. lenvatinib plus everolimus 0.87 [0.67; 1.14]0.87 [0.67;1.14]sunitinib vs. lenvatinib plus everolimus 0.87 [0.67; 1.14]sunitinib vs. nivolumab plus cabozantinib nivolumab plus cabozantinib better 1.67 [1.12; 2.49]1.67 [1.12;2.49]sunitinib vs. nivolumab plus cabozantinib nivolumab plus cabozantinib better 1.67 [1.12; 2.49]sunitinib vs. nivolumab plus ipilimumab nivolumab plus ipilimumab better 1.46 [1.16; 1.85]1.46 [1.16;1.85]sunitinib vs. nivolumab plus ipilimumab nivolumab plus ipilimumab better 1.46 [1.16; 1.85]sunitinib vs. pembrolizumab plus axitinib pembrolizumab plus axitinib better 1.89 [1.35; 2.63]1.89 [1.35;2.63]sunitinib vs. pembrolizumab plus axitinib pembrolizumab plus axitinib better 1.89 [1.35; 2.63]sunitinib vs. pembrolizumab plus lenvatinib pembrolizumab plus lenvatinib better 1.52 [1.13; 2.03]1.52 [1.13;2.03]sunitinib vs. pembrolizumab plus lenvatinib pembrolizumab plus lenvatinib better 1.52 [1.13; 2.03]sunitinibatezolizumab plus bevacizumabavelumab plus axitinibpembrolizumab plus axitinibnivolumab plus ipilimumabnivolumab plus cabozantinibatezolizumab alonepembrolizumab plus lenvatiniblenvatinib plus everolimuslenvatinib in associationdirect evidencenetwork meta-analysis
T vs. C sunitinibatezolizumab plus bevacizumabavelumab plus axitinibpembrolizumab plus axitinibnivolumab plus ipilimumabnivolumab plus cabozantinibatezolizumab alonepembrolizumab plus lenvatiniblenvatinib plus everolimuslenvatinib in association
sunitinib---1.11
0.94; 1.31
1.38
1.19; 1.60
1.89
1.35; 2.63
1.46
1.16; 1.85
1.67
1.12; 2.49
NA1.52
1.13; 2.03
0.87
0.67; 1.14
NA
atezolizumab plus bevacizumab0.90
0.76; 1.07
---1.24
0.99; 1.56
1.70
1.17; 2.47
1.32
0.99; 1.76
1.50
0.97; 2.32
NA1.37
0.97; 1.92
0.78
0.57; 1.08
NA
avelumab plus axitinib0.73
0.63; 0.84
0.80
0.64; 1.01
---1.37
0.95; 1.97
1.06
0.80; 1.40
1.21
0.79; 1.85
NA1.10
0.79; 1.53
0.63
0.46; 0.86
NA
pembrolizumab plus axitinib0.53
0.38; 0.74
0.59
0.40; 0.85
0.73
0.51; 1.05
---0.78
0.52; 1.17
0.88
0.52; 1.49
NA0.80
0.52; 1.25
0.46
0.30; 0.71
NA
nivolumab plus ipilimumab0.68
0.54; 0.86
0.76
0.57; 1.01
0.94
0.71; 1.24
1.29
0.86; 1.94
---1.14
0.72; 1.81
NA1.03
0.71; 1.51
0.59
0.42; 0.85
NA
nivolumab plus cabozantinib0.60
0.40; 0.89
0.67
0.43; 1.03
0.83
0.54; 1.27
1.13
0.67; 1.91
0.88
0.55; 1.40
---NA0.91
0.55; 1.49
0.52
0.32; 0.84
NA
atezolizumab aloneNANANANANANA---NANANA
pembrolizumab plus lenvatinib0.66
0.49; 0.88
0.73
0.52; 1.03
0.91
0.66; 1.26
1.25
0.80; 1.94
0.97
0.66; 1.41
1.10
0.67; 1.81
NA---0.57
0.39; 0.85
NA
lenvatinib plus everolimus1.15
0.88; 1.50
1.28
0.93; 1.75
1.59
1.17; 2.15
2.17
1.42; 3.32
1.68
1.18; 2.40
1.92
1.19; 3.10
NA1.74
1.17; 2.59
---NA
lenvatinib in associationNANANANANANANANANA---

pathologies: 79,178,152 - treatments: 1477 result logic