Network meta-analysis for deaths_(OS)

Network meta-analysis estimations pool direct and indirect evidences. These results should be considered as exploratory given the absence of assessment of transitivity assumption plausibility. Calculations by netmeta package.

Evidence network for deaths_(OS)

1EAGLE (D vs ICC), 20191CheckMate 141, 20162KEYNOTE-040 (all population), 2018 KEYNOTE-040 (CPS >1), 20183KEYNOTE-048 (P vs C ; all population), 2019 KEYNOTE-048 (P vs C ; CPS > 20), 2019 KEYNOTE-048 (P vs C ; CPS > 1), 20191EAGLE (DT vs ICC), 20191CONDOR (DT vs D ; PDL1 TC<25%), 20191CONDOR (DT vs T ; PDL1 TC<25%), 20193KEYNOTE-048 (PC vs C ; all population), 2019 KEYNOTE-048 (PC vs C ; CPS > 1), 2019 KEYNOTE-048 (PC vs C ; CPS > 20), 2019cetuximab plus platin plus 5FU vs. durvalumab alone 1.10 [0.83; 1.46]1.10 [0.83;1.46]cetuximab plus platin plus 5FU vs. durvalumab alone 1.10 [0.83; 1.46]cetuximab plus platin plus 5FU vs. durvalumab plus tremelimumab 1.00 [0.75; 1.32]1.00 [0.75;1.32]cetuximab plus platin plus 5FU vs. durvalumab plus tremelimumab 1.00 [0.75; 1.32]cetuximab plus platin plus 5FU vs. nivolumab alone 1.43 [0.98; 2.10]1.43 [0.98;2.10]cetuximab plus platin plus 5FU vs. nivolumab alone 1.43 [0.98; 2.10]cetuximab plus platin plus 5FU vs. pembrolizumab alone pembrolizumab alone better 1.30 [1.14; 1.47]1.30 [1.14;1.47]cetuximab plus platin plus 5FU vs. pembrolizumab alone pembrolizumab alone better 1.30 [1.14; 1.47]cetuximab plus platin plus 5FU vs. pembrolizumab plus 5FU plus platin pembrolizumab plus 5FU plus platin better 1.47 [1.29; 1.68]1.47 [1.29;1.68]cetuximab plus platin plus 5FU vs. pembrolizumab plus 5FU plus platin pembrolizumab plus 5FU plus platin better 1.47 [1.29; 1.68]cetuximab plus platin plus 5FU vs. Standard of Care (SoC) 1.00 [0.82; 1.23]1.00 [0.82;1.23]cetuximab plus platin plus 5FU vs. Standard of Care (SoC) 1.00 [0.82; 1.23]cetuximab plus platin plus 5FU vs. tremelimumab 0.72 [0.46; 1.13]0.72 [0.46;1.13]cetuximab plus platin plus 5FU vs. tremelimumab 0.72 [0.46; 1.13]durvalumab alone vs. cetuximab plus platin plus 5FU 0.91 [0.69; 1.20]0.91 [0.69;1.20]durvalumab alone vs. cetuximab plus platin plus 5FU 0.91 [0.69; 1.20]durvalumab alone vs. durvalumab plus tremelimumab 0.91 [0.72; 1.14]0.91 [0.72;1.14]durvalumab alone vs. durvalumab plus tremelimumab 0.91 [0.72; 1.14]durvalumab alone vs. nivolumab alone 1.30 [0.90; 1.90]1.30 [0.90;1.90]durvalumab alone vs. nivolumab alone 1.30 [0.90; 1.90]durvalumab alone vs. pembrolizumab alone 1.18 [0.92; 1.52]1.18 [0.92;1.52]durvalumab alone vs. pembrolizumab alone 1.18 [0.92; 1.52]durvalumab alone vs. pembrolizumab plus 5FU plus platin 1.34 [0.98; 1.83]1.34 [0.98;1.83]durvalumab alone vs. pembrolizumab plus 5FU plus platin 1.34 [0.98; 1.83]durvalumab alone vs. Standard of Care (SoC) 0.91 [0.75; 1.10]0.91 [0.75;1.10]durvalumab alone vs. Standard of Care (SoC) 0.91 [0.75; 1.10]durvalumab alone vs. tremelimumab 0.65 [0.43; 1.00]0.65 [0.43;1.00]durvalumab alone vs. tremelimumab 0.65 [0.43; 1.00]durvalumab plus tremelimumab vs. cetuximab plus platin plus 5FU 1.00 [0.76; 1.32]1.00 [0.76;1.32]durvalumab plus tremelimumab vs. cetuximab plus platin plus 5FU 1.00 [0.76; 1.32]durvalumab plus tremelimumab vs. durvalumab alone 1.10 [0.87; 1.39]1.10 [0.87;1.39]durvalumab plus tremelimumab vs. durvalumab alone 1.10 [0.87; 1.39]durvalumab plus tremelimumab vs. nivolumab alone 1.44 [0.99; 2.09]1.44 [0.99;2.09]durvalumab plus tremelimumab vs. nivolumab alone 1.44 [0.99; 2.09]durvalumab plus tremelimumab vs. pembrolizumab alone pembrolizumab alone better 1.30 [1.02; 1.67]1.30 [1.02;1.67]durvalumab plus tremelimumab vs. pembrolizumab alone pembrolizumab alone better 1.30 [1.02; 1.67]durvalumab plus tremelimumab vs. pembrolizumab plus 5FU plus platin pembrolizumab plus 5FU plus platin better 1.47 [1.08; 2.01]1.47 [1.08;2.01]durvalumab plus tremelimumab vs. pembrolizumab plus 5FU plus platin pembrolizumab plus 5FU plus platin better 1.47 [1.08; 2.01]durvalumab plus tremelimumab vs. Standard of Care (SoC) 1.01 [0.83; 1.21]1.01 [0.83;1.21]durvalumab plus tremelimumab vs. Standard of Care (SoC) 1.01 [0.83; 1.21]durvalumab plus tremelimumab vs. tremelimumab 0.72 [0.50; 1.03]0.72 [0.50;1.03]durvalumab plus tremelimumab vs. tremelimumab 0.72 [0.50; 1.03]nivolumab alone vs. cetuximab plus platin plus 5FU 0.70 [0.48; 1.02]0.70 [0.48;1.02]nivolumab alone vs. cetuximab plus platin plus 5FU 0.70 [0.48; 1.02]nivolumab alone vs. durvalumab alone 0.77 [0.53; 1.12]0.77 [0.53;1.12]nivolumab alone vs. durvalumab alone 0.77 [0.53; 1.12]nivolumab alone vs. durvalumab plus tremelimumab 0.70 [0.48; 1.01]0.70 [0.48;1.01]nivolumab alone vs. durvalumab plus tremelimumab 0.70 [0.48; 1.01]nivolumab alone vs. pembrolizumab alone 0.91 [0.63; 1.30]0.91 [0.63;1.30]nivolumab alone vs. pembrolizumab alone 0.91 [0.63; 1.30]nivolumab alone vs. pembrolizumab plus 5FU plus platin 1.03 [0.68; 1.54]1.03 [0.68;1.54]nivolumab alone vs. pembrolizumab plus 5FU plus platin 1.03 [0.68; 1.54]nivolumab alone vs. Standard of Care (SoC) nivolumab alone better 0.70 [0.51; 0.97]0.70 [0.51;0.97]nivolumab alone vs. Standard of Care (SoC) nivolumab alone better 0.70 [0.51; 0.97]nivolumab alone vs. tremelimumab nivolumab alone better 0.50 [0.30; 0.84]0.50 [0.30;0.84]nivolumab alone vs. tremelimumab nivolumab alone better 0.50 [0.30; 0.84]pembrolizumab alone vs. cetuximab plus platin plus 5FU pembrolizumab alone better 0.77 [0.68; 0.88]0.77 [0.68;0.88]pembrolizumab alone vs. cetuximab plus platin plus 5FU pembrolizumab alone better 0.77 [0.68; 0.88]pembrolizumab alone vs. durvalumab alone 0.85 [0.66; 1.09]0.85 [0.66;1.09]pembrolizumab alone vs. durvalumab alone 0.85 [0.66; 1.09]pembrolizumab alone vs. durvalumab plus tremelimumab pembrolizumab alone better 0.77 [0.60; 0.99]0.77 [0.60;0.99]pembrolizumab alone vs. durvalumab plus tremelimumab pembrolizumab alone better 0.77 [0.60; 0.99]pembrolizumab alone vs. nivolumab alone 1.10 [0.77; 1.59]1.10 [0.77;1.59]pembrolizumab alone vs. nivolumab alone 1.10 [0.77; 1.59]pembrolizumab alone vs. pembrolizumab plus 5FU plus platin 1.13 [0.94; 1.37]1.13 [0.94;1.37]pembrolizumab alone vs. pembrolizumab plus 5FU plus platin 1.13 [0.94; 1.37]pembrolizumab alone vs. Standard of Care (SoC) pembrolizumab alone better 0.77 [0.66; 0.91]0.77 [0.66;0.91]pembrolizumab alone vs. Standard of Care (SoC) pembrolizumab alone better 0.77 [0.66; 0.91]pembrolizumab alone vs. tremelimumab pembrolizumab alone better 0.55 [0.36; 0.86]0.55 [0.36;0.86]pembrolizumab alone vs. tremelimumab pembrolizumab alone better 0.55 [0.36; 0.86]pembrolizumab plus 5FU plus platin vs. cetuximab plus platin plus 5FU pembrolizumab plus 5FU plus platin better 0.68 [0.59; 0.78]0.68 [0.59;0.78]pembrolizumab plus 5FU plus platin vs. cetuximab plus platin plus 5FU pembrolizumab plus 5FU plus platin better 0.68 [0.59; 0.78]pembrolizumab plus 5FU plus platin vs. durvalumab alone 0.75 [0.55; 1.02]0.75 [0.55;1.02]pembrolizumab plus 5FU plus platin vs. durvalumab alone 0.75 [0.55; 1.02]pembrolizumab plus 5FU plus platin vs. durvalumab plus tremelimumab pembrolizumab plus 5FU plus platin better 0.68 [0.50; 0.92]0.68 [0.50;0.92]pembrolizumab plus 5FU plus platin vs. durvalumab plus tremelimumab pembrolizumab plus 5FU plus platin better 0.68 [0.50; 0.92]pembrolizumab plus 5FU plus platin vs. nivolumab alone 0.97 [0.65; 1.46]0.97 [0.65;1.46]pembrolizumab plus 5FU plus platin vs. nivolumab alone 0.97 [0.65; 1.46]pembrolizumab plus 5FU plus platin vs. pembrolizumab alone 0.88 [0.73; 1.06]0.88 [0.73;1.06]pembrolizumab plus 5FU plus platin vs. pembrolizumab alone 0.88 [0.73; 1.06]pembrolizumab plus 5FU plus platin vs. Standard of Care (SoC) pembrolizumab plus 5FU plus platin better 0.68 [0.53; 0.87]0.68 [0.53;0.87]pembrolizumab plus 5FU plus platin vs. Standard of Care (SoC) pembrolizumab plus 5FU plus platin better 0.68 [0.53; 0.87]pembrolizumab plus 5FU plus platin vs. tremelimumab pembrolizumab plus 5FU plus platin better 0.49 [0.30; 0.78]0.49 [0.30;0.78]pembrolizumab plus 5FU plus platin vs. tremelimumab pembrolizumab plus 5FU plus platin better 0.49 [0.30; 0.78]Standard of Care (SoC) vs. cetuximab plus platin plus 5FU 1.00 [0.81; 1.23]1.00 [0.81;1.23]Standard of Care (SoC) vs. cetuximab plus platin plus 5FU 1.00 [0.81; 1.23]Standard of Care (SoC) vs. durvalumab alone 1.10 [0.91; 1.33]1.10 [0.91;1.33]Standard of Care (SoC) vs. durvalumab alone 1.10 [0.91; 1.33]Standard of Care (SoC) vs. durvalumab plus tremelimumab 0.99 [0.82; 1.20]0.99 [0.82;1.20]Standard of Care (SoC) vs. durvalumab plus tremelimumab 0.99 [0.82; 1.20]Standard of Care (SoC) vs. nivolumab alone nivolumab alone better 1.43 [1.03; 1.97]1.43 [1.03;1.97]Standard of Care (SoC) vs. nivolumab alone nivolumab alone better 1.43 [1.03; 1.97]Standard of Care (SoC) vs. pembrolizumab alone pembrolizumab alone better 1.29 [1.10; 1.52]1.29 [1.10;1.52]Standard of Care (SoC) vs. pembrolizumab alone pembrolizumab alone better 1.29 [1.10; 1.52]Standard of Care (SoC) vs. pembrolizumab plus 5FU plus platin pembrolizumab plus 5FU plus platin better 1.47 [1.15; 1.88]1.47 [1.15;1.88]Standard of Care (SoC) vs. pembrolizumab plus 5FU plus platin pembrolizumab plus 5FU plus platin better 1.47 [1.15; 1.88]Standard of Care (SoC) vs. tremelimumab 0.72 [0.48; 1.07]0.72 [0.48;1.07]Standard of Care (SoC) vs. tremelimumab 0.72 [0.48; 1.07]tremelimumab vs. cetuximab plus platin plus 5FU 1.39 [0.88; 2.19]1.39 [0.88;2.19]tremelimumab vs. cetuximab plus platin plus 5FU 1.39 [0.88; 2.19]tremelimumab vs. durvalumab alone 1.53 [1.00; 2.35]1.53 [1.00;2.35]tremelimumab vs. durvalumab alone 1.53 [1.00; 2.35]tremelimumab vs. durvalumab plus tremelimumab 1.39 [0.97; 1.99]1.39 [0.97;1.99]tremelimumab vs. durvalumab plus tremelimumab 1.39 [0.97; 1.99]tremelimumab vs. nivolumab alone nivolumab alone better 1.99 [1.19; 3.35]1.99 [1.19;3.35]tremelimumab vs. nivolumab alone nivolumab alone better 1.99 [1.19; 3.35]tremelimumab vs. pembrolizumab alone pembrolizumab alone better 1.81 [1.17; 2.79]1.81 [1.17;2.79]tremelimumab vs. pembrolizumab alone pembrolizumab alone better 1.81 [1.17; 2.79]tremelimumab vs. pembrolizumab plus 5FU plus platin pembrolizumab plus 5FU plus platin better 2.05 [1.28; 3.29]2.05 [1.28;3.29]tremelimumab vs. pembrolizumab plus 5FU plus platin pembrolizumab plus 5FU plus platin better 2.05 [1.28; 3.29]tremelimumab vs. Standard of Care (SoC) 1.40 [0.93; 2.09]1.40 [0.93;2.09]tremelimumab vs. Standard of Care (SoC) 1.40 [0.93; 2.09]Standard of Care (SoC)cetuximab plus platin plus 5FUdurvalumab alonetremelimumabnivolumab alonepembrolizumab alonedurvalumab plus tremelimumabpembrolizumab plus 5FU plus platindirect evidencenetwork meta-analysis
T vs. C Standard of Care (SoC)cetuximab plus platin plus 5FUdurvalumab alonetremelimumabnivolumab alonepembrolizumab alonedurvalumab plus tremelimumabpembrolizumab plus 5FU plus platin
Standard of Care (SoC)---1.00
0.81; 1.23
1.10
0.91; 1.33
0.72
0.48; 1.07
1.43
1.03; 1.97
1.29
1.10; 1.52
0.99
0.82; 1.20
1.47
1.15; 1.88
cetuximab plus platin plus 5FU1.00
0.82; 1.23
---1.10
0.83; 1.46
0.72
0.46; 1.13
1.43
0.98; 2.10
1.30
1.14; 1.47
1.00
0.75; 1.32
1.47
1.29; 1.68
durvalumab alone0.91
0.75; 1.10
0.91
0.69; 1.20
---0.65
0.43; 1.00
1.30
0.90; 1.90
1.18
0.92; 1.52
0.91
0.72; 1.14
1.34
0.98; 1.83
tremelimumab1.40
0.93; 2.09
1.39
0.88; 2.19
1.53
1.00; 2.35
---1.99
1.19; 3.35
1.81
1.17; 2.79
1.39
0.97; 1.99
2.05
1.28; 3.29
nivolumab alone0.70
0.51; 0.97
0.70
0.48; 1.02
0.77
0.53; 1.12
0.50
0.30; 0.84
---0.91
0.63; 1.30
0.70
0.48; 1.01
1.03
0.68; 1.54
pembrolizumab alone0.77
0.66; 0.91
0.77
0.68; 0.88
0.85
0.66; 1.09
0.55
0.36; 0.86
1.10
0.77; 1.59
---0.77
0.60; 0.99
1.13
0.94; 1.37
durvalumab plus tremelimumab1.01
0.83; 1.21
1.00
0.76; 1.32
1.10
0.87; 1.39
0.72
0.50; 1.03
1.44
0.99; 2.09
1.30
1.02; 1.67
---1.47
1.08; 2.01
pembrolizumab plus 5FU plus platin0.68
0.53; 0.87
0.68
0.59; 0.78
0.75
0.55; 1.02
0.49
0.30; 0.78
0.97
0.65; 1.46
0.88
0.73; 1.06
0.68
0.50; 0.92
---

pathologies: 276,103,277,102,109,278,101,192,114 - treatments: 875 result logic