meta
|
evidence
oncology
Living systematic review and meta-analysis
locally advanced (laHNSCC)
laHNSCC - (neo)adjuvant (NA)
laHNSCC - 1st line (L1)
1
laHNSCC - 2nd line (L2)
<span style="margin-left: 0em;">immune chekpoint inhibitors</span>
<span style="margin-left: 1em;">anti-PD-(L)1</span>
<span style="margin-left: 2em;">avelumab based treatment</span>
<span style="margin-left: 3em;">avelumab alone <i class='fa fa-circle' style='color: royalblue; font-size: 10px;'></i></span>
<span style="margin-left: 0em;">non active control</span>
<span style="margin-left: 1em;">placebo <i class='fa fa-circle' style='color: royalblue; font-size: 10px;'></i></span>
Select endpoint...
deaths (OS) (1)
progression or deaths (PFS) (1)
objective responses (ORR) (1)
DOR (1)
TRAE (grade 3-4) (2)
AE (any grade) (1)
TRAE (any grade) (1)
AE (grade 3-4) (1)
TRAE leading to death (grade 5) (1)
STRAE (any grade) (1)
Rash TRAE (grade 3-4) (1)
Diarrhoea TRAE (grade 3-4) (1)
Colitis TRAE (grade 3-4) (1)
Increased ALT TRAE (grade 3-4) (1)
Increase AST TRAE (grade 3-4) (1)
Hypothyroidism TRAE (grade 3-4) (1)
Hyperthyroidism TRAE (grade 3-4) (1)
Fatigue TRAE (grade 3-4) (1)
Nausea TRAE (grade 3-4) (1)
Anaemia TRAE (grade 3-4) (1)
Decreased appetite TRAE (grade 3-4) (1)
Asthenia TRAE (grade 3-4) (1)
Pyrexia TRAE (grade 3-4) (1)
Pneumonitis TRAE (grade 3-4) (1)
Thrombocytopenia TRAE (grade 3-4) (1)
Neutropenia TRAE (grade 3-4) (1)
Vomiting TRAE (grade 3-4) (1)
Constipation TRAE (grade 3-4) (1)
Leucopenia TRAE (grade 3-4) (1)
Cough TRAE (grade 3-4) (1)
Abdominal pain TRAE (grade 3-4) (1)
Headache TRAE (grade 3-4) (1)
Increased lipase level TRAE (grade 3-4) (1)
Adrenal insufficiency TRAE (grade 3-4) (1)
Chills TRAE (grade 3-4) (1)
Nephritis TRAE (grade 3-4) (1)
Peripheral neuropathy TRAE (grade 3-4) (1)
Weight decreased TRAE (grade 3-4) (1)
Peripheral oedema TRAE (grade 3-4) (1)
Mucosal inflammation TRAE (grade 3-4) (1)
Dysgeusia TRAE (grade 3-4) (1)
Stomatitis TRAE (grade 3-4) (1)
Hypertension TRAE (grade 3-4) (1)
Urticaria TRAE (grade 3-4) (1)
Acute kidney injury TRAE (grade 3-4) (1)
Blood creatinine increased TRAE (grade 3-4) (1)
Infusion-related reactions TRAE (grade 3-4) (1)
Dysphonia TRAE (grade 3-4) (1)
Febrile neutropenia TRAE (grade 3-4) (1)
Pancytopenia TRAE (grade 3-4) (1)
Sepsis TRAE (grade 3-4) (1)
Pneumonia TRAE (grade 3-4) (1)
study list
mapping
overview
meta-analysis
forest plot
NMA
excluded
insufficient data
Evidence network for deaths (OS)
1
JAVELIN Head and Neck 100, 2021
placebo
avelumab alone
direct evidence
network meta-analysis
comet plot
result box
odds ratio
A
B
0.5
1.5
1.0
odds ratio for A vs. B
and half 95% CI
T
vs.
C
placebo
avelumab alone
placebo
---
NA
avelumab alone
NA
---
pathologies: 104 - treatments: 417
result logic
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Study list
