Network meta-analysis for deaths_(OS)

Network meta-analysis estimations pool direct and indirect evidences. These results should be considered as exploratory given the absence of assessment of transitivity assumption plausibility. Calculations by netmeta package.

Evidence network for deaths_(OS)

1KEYNOTE-048 (P vs C ; all population), 20191KEYNOTE-048 (PC vs C ; all population), 2019cetuximab plus platin plus 5FU vs. pembrolizumab alone pembrolizumab alone better 1.20 [1.01; 1.43]1.20 [1.01;1.43]cetuximab plus platin plus 5FU vs. pembrolizumab alone pembrolizumab alone better 1.20 [1.01; 1.43]cetuximab plus platin plus 5FU vs. pembrolizumab plus 5FU plus platin pembrolizumab plus 5FU plus platin better 1.30 [1.07; 1.58]1.30 [1.07;1.58]cetuximab plus platin plus 5FU vs. pembrolizumab plus 5FU plus platin pembrolizumab plus 5FU plus platin better 1.30 [1.07; 1.58]pembrolizumab alone vs. cetuximab plus platin plus 5FU pembrolizumab alone better 0.83 [0.70; 0.99]0.83 [0.70;0.99]pembrolizumab alone vs. cetuximab plus platin plus 5FU pembrolizumab alone better 0.83 [0.70; 0.99]pembrolizumab alone vs. pembrolizumab plus 5FU plus platin 1.08 [0.83; 1.40]1.08 [0.83;1.40]pembrolizumab alone vs. pembrolizumab plus 5FU plus platin 1.08 [0.83; 1.40]pembrolizumab plus 5FU plus platin vs. cetuximab plus platin plus 5FU pembrolizumab plus 5FU plus platin better 0.77 [0.63; 0.94]0.77 [0.63;0.94]pembrolizumab plus 5FU plus platin vs. cetuximab plus platin plus 5FU pembrolizumab plus 5FU plus platin better 0.77 [0.63; 0.94]pembrolizumab plus 5FU plus platin vs. pembrolizumab alone 0.93 [0.71; 1.20]0.93 [0.71;1.20]pembrolizumab plus 5FU plus platin vs. pembrolizumab alone 0.93 [0.71; 1.20]cetuximab plus platin plus 5FUpembrolizumab alonepembrolizumab plus 5FU plus platindirect evidencenetwork meta-analysis
T vs. C cetuximab plus platin plus 5FUpembrolizumab alonepembrolizumab plus 5FU plus platin
cetuximab plus platin plus 5FU---1.20
1.01; 1.43		1.30
1.07; 1.58
pembrolizumab alone0.83
0.70; 0.99		---1.08
0.83; 1.40
pembrolizumab plus 5FU plus platin0.77
0.63; 0.94		0.93
0.71; 1.20		---

pathologies: 102 - treatments: 875 result logic

 

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