Study study type PathologyT1T0Patientssample sizesROB Results

mGC or mGEJC - L1 - HER2 neg/PDL1 positive metastatic/advanced mGC or mGEJC mGC or mGEJC - 1st line (L1) mGC or mGEJC - L1 - HER2 neg/PDL1 positive

versus Standard of Care (SoC)
nivolumab plus SoC
CheckMate 649 (PDL1 CPS>5), 2021
  NCT02872116
RCTmGC or mGEJC - L1 - HER2 neg/PDL1 positivenivolumab plus chemotherapyICC (XELOX, FOLFOX)previously untreated, non-HER2-positive, advanced or metastatic gastric cancer, GEJ cancer or esophageal adenocarcinoma, only patients with PDL1 CPS>5473 / 482some concern
conclusif
  • demonstrated 29 % decrease in deaths (OS) (PE)
  • demonstrated 32 % decrease in progression or deaths (PFS) (PE)
CheckMate 649 (PDL1 CPS>1), 2021
  NCT02872116
RCTmGC or mGEJC - L1 - HER2 neg/PDL1 positivenivolumab plus chemotherapyICC (XELOX, FOLFOX)previously untreated, non-HER2-positive, advanced or metastatic gastric cancer, GEJ cancer or esophageal adenocarcinoma, only patients with PDL1 CPS>1641 / 655some concern
conclusif
  • demonstrated 23 % decrease in deaths (OS) (PE)
  • suggested 26 % decrease in progression or deaths (PFS)

mGC or mGEJC - L1 - HER2 negative metastatic/advanced mGC or mGEJC mGC or mGEJC - 1st line (L1) mGC or mGEJC - L1 - HER2 negative

versus Standard of Care (SoC)
nivolumab plus SoC
CheckMate 649, 2021
  NCT02872116
RCTmGC or mGEJC - L1 - HER2 negativenivolumab plus chemotherapyICC (XELOX, FOLFOX)previously untreated, non-HER2-positive, advanced or metastatic gastric cancer, GEJ cancer or esophageal adenocarcinoma789 / 792some concern
conclusif
  • demonstrated 20 % decrease in deaths (OS) (PE)
  • suggested 23 % decrease in progression or deaths (PFS)