metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results
mNSCLC - L2 - EGFR mutant metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2) mNSCLC - L2 - EGFR mutant
versus osimertinib
	durvalumab plus osimertinib
	CAURAL (EXPLORATORY), 2019 J Thorac Oncol 2019 May;14(5):933-939. NCT02454933	RCT	mNSCLC - L2 - EGFR mutant	durvalumab plus osimertinib	osimertinib	Patients with EGFR T790M mutation positive locally advanced/metastatic NSCLC (stage IIIB–IV) (previous treatment 1 to >4)	14 / 15	some concern	inconclusive	no statistically significant result
mNSCLC - L2 - PDL1 positive metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2) mNSCLC - L2 - PDL1 positive
versus Standard of Care (SoC)
	durvalumab alone
	ARCTIC (D ; study A ; PDL1>25% EXPLORATORY), 2020 Clin Lung Cancer 2016; 17:232-236.e1 Ann Oncol 2020 May;31(5):609-618. NCT02352948	RCT	mNSCLC - L2 - PDL1 positive	durvalumab	standard of care : erlotinib, gemcitabine or vinorelbine	patients with PD-L1 positive locally advanced or metastatic non small cell lung cancer who have received at least 2 prior systemic treatment regimens including 1 platinum-based chemotherapy regimen for stage IIIB/IV locally advanced or mNSCLC;	62 / 64	some concern	suggested	suggested 37 % decrease in deaths (OS)