Study study type PathologyT1T0Patientssample sizesROB Results

malignant mesothelioma (mMS) - 1st line (L1) malignant mesothelioma (mMS) - 1st line (L1)

versus pemetrexed plus platin
nivolumab plus ipilimumab
CheckMate 743, 2021
  NCT02899299
RCTmalignant mesothelioma (mMS) - 1st line (L1)nivolumab plus ipilimumabcisplatin or carboplatin plus pemetrexedfirst-line treatment of patients with unresectable malignant pleural mesothelioma303 / 302some concern
conclusif
  • demonstrated 26 % decrease in deaths (OS) (PE)
  • statistically significant 43 % decrease in DCR