Network meta-analysis for deaths_(OS)

Network meta-analysis estimations pool direct and indirect evidences. These results should be considered as exploratory given the absence of assessment of transitivity assumption plausibility. Calculations by netmeta package.

Evidence network for deaths_(OS)

2IMpassion-130 (all population), 2018 IMpassion-130 (PDL1>1%), 20182IMpassion-131 (PD-L1 > 1%), 2020 IMpassion-131 (all population), 20203KEYNOTE-355 (all population), 2020 KEYNOTE-355 (CPS>1), 2020 KEYNOTE-355 (CPS>10), 20202PAKT (all population), 2020 PAKT (PIK3CA/AKT1/PTEN-altered), 20201LOTUS, 20171BrighTNess (velaparib-P-C (arm A) vs paclitaxel alone (arm C)), 2018atezolizumab plus nab-paclitaxel vs. atezolizumab plus paclitaxel atezolizumab plus nab-paclitaxel better 0.73 [0.57; 0.94]0.73 [0.57;0.94]atezolizumab plus nab-paclitaxel vs. atezolizumab plus paclitaxel atezolizumab plus nab-paclitaxel better 0.73 [0.57; 0.94]atezolizumab plus nab-paclitaxel vs. capivasertib plus paclitaxel 1.45 [0.90; 2.33]1.45 [0.90;2.33]atezolizumab plus nab-paclitaxel vs. capivasertib plus paclitaxel 1.45 [0.90; 2.33]atezolizumab plus nab-paclitaxel vs. ipatasertib plus paclitaxel 1.02 [0.62; 1.67]1.02 [0.62;1.67]atezolizumab plus nab-paclitaxel vs. ipatasertib plus paclitaxel 1.02 [0.62; 1.67]atezolizumab plus nab-paclitaxel vs. pembrolizumab plus SoC 0.96 [0.80; 1.15]0.96 [0.80;1.15]atezolizumab plus nab-paclitaxel vs. pembrolizumab plus SoC 0.96 [0.80; 1.15]atezolizumab plus nab-paclitaxel vs. Standard of Care (SoC) atezolizumab plus nab-paclitaxel better 0.81 [0.70; 0.94]0.81 [0.70;0.94]atezolizumab plus nab-paclitaxel vs. Standard of Care (SoC) atezolizumab plus nab-paclitaxel better 0.81 [0.70; 0.94]atezolizumab plus nab-paclitaxel vs. veliparib plus paclitaxel plus carboplatin 0.99 [0.57; 1.72]0.99 [0.57;1.72]atezolizumab plus nab-paclitaxel vs. veliparib plus paclitaxel plus carboplatin 0.99 [0.57; 1.72]atezolizumab plus paclitaxel vs. atezolizumab plus nab-paclitaxel atezolizumab plus nab-paclitaxel better 1.37 [1.07; 1.77]1.37 [1.07;1.77]atezolizumab plus paclitaxel vs. atezolizumab plus nab-paclitaxel atezolizumab plus nab-paclitaxel better 1.37 [1.07; 1.77]atezolizumab plus paclitaxel vs. capivasertib plus paclitaxel capivasertib plus paclitaxel better 1.99 [1.21; 3.26]1.99 [1.21;3.26]atezolizumab plus paclitaxel vs. capivasertib plus paclitaxel capivasertib plus paclitaxel better 1.99 [1.21; 3.26]atezolizumab plus paclitaxel vs. ipatasertib plus paclitaxel 1.40 [0.84; 2.33]1.40 [0.84;2.33]atezolizumab plus paclitaxel vs. ipatasertib plus paclitaxel 1.40 [0.84; 2.33]atezolizumab plus paclitaxel vs. pembrolizumab plus SoC pembrolizumab plus SoC better 1.31 [1.04; 1.66]1.31 [1.04;1.66]atezolizumab plus paclitaxel vs. pembrolizumab plus SoC pembrolizumab plus SoC better 1.31 [1.04; 1.66]atezolizumab plus paclitaxel vs. Standard of Care (SoC) 1.12 [0.91; 1.37]1.12 [0.91;1.37]atezolizumab plus paclitaxel vs. Standard of Care (SoC) 1.12 [0.91; 1.37]atezolizumab plus paclitaxel vs. veliparib plus paclitaxel plus carboplatin 1.36 [0.77; 2.40]1.36 [0.77;2.40]atezolizumab plus paclitaxel vs. veliparib plus paclitaxel plus carboplatin 1.36 [0.77; 2.40]capivasertib plus paclitaxel vs. atezolizumab plus nab-paclitaxel 0.69 [0.43; 1.11]0.69 [0.43;1.11]capivasertib plus paclitaxel vs. atezolizumab plus nab-paclitaxel 0.69 [0.43; 1.11]capivasertib plus paclitaxel vs. atezolizumab plus paclitaxel capivasertib plus paclitaxel better 0.50 [0.31; 0.83]0.50 [0.31;0.83]capivasertib plus paclitaxel vs. atezolizumab plus paclitaxel capivasertib plus paclitaxel better 0.50 [0.31; 0.83]capivasertib plus paclitaxel vs. ipatasertib plus paclitaxel 0.70 [0.37; 1.35]0.70 [0.37;1.35]capivasertib plus paclitaxel vs. ipatasertib plus paclitaxel 0.70 [0.37; 1.35]capivasertib plus paclitaxel vs. pembrolizumab plus SoC 0.66 [0.42; 1.05]0.66 [0.42;1.05]capivasertib plus paclitaxel vs. pembrolizumab plus SoC 0.66 [0.42; 1.05]capivasertib plus paclitaxel vs. Standard of Care (SoC) capivasertib plus paclitaxel better 0.56 [0.36; 0.88]0.56 [0.36;0.88]capivasertib plus paclitaxel vs. Standard of Care (SoC) capivasertib plus paclitaxel better 0.56 [0.36; 0.88]capivasertib plus paclitaxel vs. veliparib plus paclitaxel plus carboplatin 0.69 [0.34; 1.37]0.69 [0.34;1.37]capivasertib plus paclitaxel vs. veliparib plus paclitaxel plus carboplatin 0.69 [0.34; 1.37]ipatasertib plus paclitaxel vs. atezolizumab plus nab-paclitaxel 0.98 [0.60; 1.61]0.98 [0.60;1.61]ipatasertib plus paclitaxel vs. atezolizumab plus nab-paclitaxel 0.98 [0.60; 1.61]ipatasertib plus paclitaxel vs. atezolizumab plus paclitaxel 0.72 [0.43; 1.20]0.72 [0.43;1.20]ipatasertib plus paclitaxel vs. atezolizumab plus paclitaxel 0.72 [0.43; 1.20]ipatasertib plus paclitaxel vs. capivasertib plus paclitaxel 1.42 [0.74; 2.73]1.42 [0.74;2.73]ipatasertib plus paclitaxel vs. capivasertib plus paclitaxel 1.42 [0.74; 2.73]ipatasertib plus paclitaxel vs. pembrolizumab plus SoC 0.94 [0.58; 1.52]0.94 [0.58;1.52]ipatasertib plus paclitaxel vs. pembrolizumab plus SoC 0.94 [0.58; 1.52]ipatasertib plus paclitaxel vs. Standard of Care (SoC) 0.80 [0.50; 1.28]0.80 [0.50;1.28]ipatasertib plus paclitaxel vs. Standard of Care (SoC) 0.80 [0.50; 1.28]ipatasertib plus paclitaxel vs. veliparib plus paclitaxel plus carboplatin 0.98 [0.48; 1.98]0.98 [0.48;1.98]ipatasertib plus paclitaxel vs. veliparib plus paclitaxel plus carboplatin 0.98 [0.48; 1.98]pembrolizumab plus SoC vs. atezolizumab plus nab-paclitaxel 1.04 [0.87; 1.26]1.04 [0.87;1.26]pembrolizumab plus SoC vs. atezolizumab plus nab-paclitaxel 1.04 [0.87; 1.26]pembrolizumab plus SoC vs. atezolizumab plus paclitaxel pembrolizumab plus SoC better 0.76 [0.60; 0.96]0.76 [0.60;0.96]pembrolizumab plus SoC vs. atezolizumab plus paclitaxel pembrolizumab plus SoC better 0.76 [0.60; 0.96]pembrolizumab plus SoC vs. capivasertib plus paclitaxel 1.51 [0.95; 2.41]1.51 [0.95;2.41]pembrolizumab plus SoC vs. capivasertib plus paclitaxel 1.51 [0.95; 2.41]pembrolizumab plus SoC vs. ipatasertib plus paclitaxel 1.06 [0.66; 1.72]1.06 [0.66;1.72]pembrolizumab plus SoC vs. ipatasertib plus paclitaxel 1.06 [0.66; 1.72]pembrolizumab plus SoC vs. Standard of Care (SoC) pembrolizumab plus SoC better 0.85 [0.76; 0.95]0.85 [0.76;0.95]pembrolizumab plus SoC vs. Standard of Care (SoC) pembrolizumab plus SoC better 0.85 [0.76; 0.95]pembrolizumab plus SoC vs. veliparib plus paclitaxel plus carboplatin 1.04 [0.60; 1.78]1.04 [0.60;1.78]pembrolizumab plus SoC vs. veliparib plus paclitaxel plus carboplatin 1.04 [0.60; 1.78]Standard of Care (SoC) vs. atezolizumab plus nab-paclitaxel atezolizumab plus nab-paclitaxel better 1.23 [1.06; 1.42]1.23 [1.06;1.42]Standard of Care (SoC) vs. atezolizumab plus nab-paclitaxel atezolizumab plus nab-paclitaxel better 1.23 [1.06; 1.42]Standard of Care (SoC) vs. atezolizumab plus paclitaxel 0.90 [0.73; 1.10]0.90 [0.73;1.10]Standard of Care (SoC) vs. atezolizumab plus paclitaxel 0.90 [0.73; 1.10]Standard of Care (SoC) vs. capivasertib plus paclitaxel capivasertib plus paclitaxel better 1.78 [1.13; 2.79]1.78 [1.13;2.79]Standard of Care (SoC) vs. capivasertib plus paclitaxel capivasertib plus paclitaxel better 1.78 [1.13; 2.79]Standard of Care (SoC) vs. ipatasertib plus paclitaxel 1.25 [0.78; 2.00]1.25 [0.78;2.00]Standard of Care (SoC) vs. ipatasertib plus paclitaxel 1.25 [0.78; 2.00]Standard of Care (SoC) vs. pembrolizumab plus SoC pembrolizumab plus SoC better 1.18 [1.05; 1.31]1.18 [1.05;1.31]Standard of Care (SoC) vs. pembrolizumab plus SoC pembrolizumab plus SoC better 1.18 [1.05; 1.31]Standard of Care (SoC) vs. veliparib plus paclitaxel plus carboplatin 1.22 [0.72; 2.07]1.22 [0.72;2.07]Standard of Care (SoC) vs. veliparib plus paclitaxel plus carboplatin 1.22 [0.72; 2.07]veliparib plus paclitaxel plus carboplatin vs. atezolizumab plus nab-paclitaxel 1.01 [0.58; 1.74]1.01 [0.58;1.74]veliparib plus paclitaxel plus carboplatin vs. atezolizumab plus nab-paclitaxel 1.01 [0.58; 1.74]veliparib plus paclitaxel plus carboplatin vs. atezolizumab plus paclitaxel 0.73 [0.42; 1.29]0.73 [0.42;1.29]veliparib plus paclitaxel plus carboplatin vs. atezolizumab plus paclitaxel 0.73 [0.42; 1.29]veliparib plus paclitaxel plus carboplatin vs. capivasertib plus paclitaxel 1.46 [0.73; 2.92]1.46 [0.73;2.92]veliparib plus paclitaxel plus carboplatin vs. capivasertib plus paclitaxel 1.46 [0.73; 2.92]veliparib plus paclitaxel plus carboplatin vs. ipatasertib plus paclitaxel 1.02 [0.51; 2.08]1.02 [0.51;2.08]veliparib plus paclitaxel plus carboplatin vs. ipatasertib plus paclitaxel 1.02 [0.51; 2.08]veliparib plus paclitaxel plus carboplatin vs. pembrolizumab plus SoC 0.96 [0.56; 1.65]0.96 [0.56;1.65]veliparib plus paclitaxel plus carboplatin vs. pembrolizumab plus SoC 0.96 [0.56; 1.65]veliparib plus paclitaxel plus carboplatin vs. Standard of Care (SoC) 0.82 [0.48; 1.39]0.82 [0.48;1.39]veliparib plus paclitaxel plus carboplatin vs. Standard of Care (SoC) 0.82 [0.48; 1.39]Standard of Care (SoC)placebo plus SoCatezolizumab plus nab-paclitaxelatezolizumab plus paclitaxelpembrolizumab plus SoCcapivasertib plus paclitaxelipatasertib plus paclitaxelveliparib plus paclitaxel plus carboplatindirect evidencenetwork meta-analysis
T vs. C Standard of Care (SoC)placebo plus SoCatezolizumab plus nab-paclitaxelatezolizumab plus paclitaxelpembrolizumab plus SoCcapivasertib plus paclitaxelipatasertib plus paclitaxelveliparib plus paclitaxel plus carboplatin
Standard of Care (SoC)---NA1.23
1.06; 1.42
0.90
0.73; 1.10
1.18
1.05; 1.31
1.78
1.13; 2.79
1.25
0.78; 2.00
1.22
0.72; 2.07
placebo plus SoCNA---NANANANANANA
atezolizumab plus nab-paclitaxel0.81
0.70; 0.94
NA---0.73
0.57; 0.94
0.96
0.80; 1.15
1.45
0.90; 2.33
1.02
0.62; 1.67
0.99
0.57; 1.72
atezolizumab plus paclitaxel1.12
0.91; 1.37
NA1.37
1.07; 1.77
---1.31
1.04; 1.66
1.99
1.21; 3.26
1.40
0.84; 2.33
1.36
0.77; 2.40
pembrolizumab plus SoC0.85
0.76; 0.95
NA1.04
0.87; 1.26
0.76
0.60; 0.96
---1.51
0.95; 2.41
1.06
0.66; 1.72
1.04
0.60; 1.78
capivasertib plus paclitaxel0.56
0.36; 0.88
NA0.69
0.43; 1.11
0.50
0.31; 0.83
0.66
0.42; 1.05
---0.70
0.37; 1.35
0.69
0.34; 1.37
ipatasertib plus paclitaxel0.80
0.50; 1.28
NA0.98
0.60; 1.61
0.72
0.43; 1.20
0.94
0.58; 1.52
1.42
0.74; 2.73
---0.98
0.48; 1.98
veliparib plus paclitaxel plus carboplatin0.82
0.48; 1.39
NA1.01
0.58; 1.74
0.73
0.42; 1.29
0.96
0.56; 1.65
1.46
0.73; 2.92
1.02
0.51; 2.08
---

pathologies: 269,60,143 - treatments: 1252 result logic