deaths (OS)progression or deaths (PFS)RFS/DFS

la/mBC - HR-positive - 2nd line (L2) breast cancer - HR positive la/mBC - HR positive la/mBC - HR-positive - 2nd line (L2)

versus endocrine therapy
ribociclib plus endocrine therapy vs. endocrine therapy 1 ---
versus fulvestrant
abemaciclib plus fulvestrant vs. fulvestrant 1 ---
dalpiciclib plus fulvestrant vs. fulvestrant 1 - certainty unassessablestatistically conclusive-53%-
palbociclib plus fulvestrant vs. fulvestrant 2 certainty unassessable-17%statistically conclusive-50%-
ribociclib plus fulvestrant vs. fulvestrant 1 ---

la/mBC - HR positive - L2 - all population breast cancer - HR positive la/mBC - HR positive la/mBC - HR-positive - 2nd line (L2) la/mBC - HR positive - L2 - all population

la/mBC - HR positive - L2 - PIK3CA mutant breast cancer - HR positive la/mBC - HR positive la/mBC - HR-positive - 2nd line (L2) la/mBC - HR positive - L2 - PIK3CA mutant