button bars forest bayes pooled summary circles
 
DCR

mML - NA - all population metastatic/adv melanoma (mML) mML - (neo)adjuvant (NA) mML - NA - all population

versus interferon alpha
Ipilimumab (10 mg/kg) vs. interferon alpha 1 -
ipilimumab alone vs. interferon alpha 1 -
versus Ipilimumab (10 mg/kg)
nivolumab alone vs. Ipilimumab (10 mg/kg) 1 -
versus nivolumab alone
nivolumab plus ipilimumab vs. nivolumab alone 1 -
versus placebo
Ipilimumab (10 mg/kg) vs. placebo 1 -
nivolumab alone vs. placebo 1 -
nivolumab plus ipilimumab vs. placebo 1 -
pembrolizumab alone vs. placebo 1 -

mML - NA - PDL1 positive metastatic/adv melanoma (mML) mML - (neo)adjuvant (NA) mML - NA - PDL1 positive

versus placebo
pembrolizumab alone vs. placebo 1 -

mML - L1 - all population metastatic/adv melanoma (mML) mML - 1st line (L1) mML - L1 - all population

versus ipilimumab alone
nivolumab alone vs. ipilimumab alone 1 -
nivolumab plus ipilimumab vs. ipilimumab alone 2 -
versus ipilimumab followed by nivolumab
nivolumab followed by ipilimumab vs. ipilimumab followed by nivolumab 1 -
versus nivolumab alone
nivolumab plus ipilimumab vs. nivolumab alone 1 -
relatlimab plus nivolumab vs. nivolumab alone 1 -
versus Standard of Care (SoC)
tremelimumab vs. Standard of Care (SoC) 1 -

mML - L1 - BRAF mutant metastatic/adv melanoma (mML) mML - 1st line (L1) mML - L1 - BRAF mutant

versus ipilimumab alone
nivolumab plus ipilimumab vs. ipilimumab alone 1 -
versus placebo plus SoC
atezolizumab plus SoC vs. placebo plus SoC 1 -

mML - L1 - BRAF wild metastatic/adv melanoma (mML) mML - 1st line (L1) mML - L1 - BRAF wild

versus dacarbazine
nivolumab alone vs. dacarbazine 1 -
versus ipilimumab alone
nivolumab plus ipilimumab vs. ipilimumab alone 1 -
versus pembrolizumab alone
atezolizumab plus cometinib vs. pembrolizumab alone 1 certainty unassessable-8%

mML - L2 - all population metastatic/adv melanoma (mML) mML - 2nd line (L2) mML - L2 - all population

versus gp100
ipilimumab alone vs. gp100 1 -
ipilimumab plus gp100 vs. gp100 1 -
versus ipilimumab alone
Ipilimumab (10 mg/kg) vs. ipilimumab alone 1 certainty unassessable+19%
ipilimumab plus gp100 vs. ipilimumab alone 1 -
pembrolizumab (10mg/kg) vs. ipilimumab alone 1 -
pembrolizumab (10mg/kg) 2 weeks vs. ipilimumab alone 1 -
versus placebo plus SoC
ipilimumab plus SoC vs. placebo plus SoC 1 certainty unassessable+15%
versus Standard of Care (SoC)
nivolumab alone vs. Standard of Care (SoC) 1 -
pembrolizumab (10mg/kg) vs. Standard of Care (SoC) 1 -
pembrolizumab (2mg/kg) vs. Standard of Care (SoC) 1 -

mML - L2 - BRAF mutant metastatic/adv melanoma (mML) mML - 2nd line (L2) mML - L2 - BRAF mutant

versus placebo plus SoC
pembrolizumab plus SoC vs. placebo plus SoC 1 -

 

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