Study explorer (study characteristics and results) method abbreviations pdf   xlsx

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Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

Declercq J (COV-AID)
 
NCT04330638
RCTtocilizumab standard of careCOVID 19 hospitalizedlow
114/115 inconclusive
    RCT-TCZ-COVID-19
     
    NCT04346355
    RCTtocilizumab standard of careCOVID 19 hospitalizedsome concern
    60/66 inconclusive
      RECOVERY
       
      NCT04381936
      RCTtocilizumab standard of careCOVID 19 hospitalizedsome concern
      2022/2094 conclusif
      • demonstrated 15 % decrease in deaths (PE) with a moderate degree of certainty due to some concern in risk of bias
      • suggested 15 % decrease in death or ventilation with a moderate degree of certainty due to some concern in risk of bias
      Rutgers RCTtocilizumab standard of careCOVID 19 hospitalizedsome concern
      174/180 suggested
      • inconclusive 41 % decrease in death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
      • suggested 35 % decrease in death or ventilation with a moderate degree of certainty due to some concern in risk of bias
      Soin AS (COVINTOC)
       
      CTRI/2020/05/025369
      RCTtocilizumab standard of careCOVID 19 hospitalizedsome concern
      90/90 inconclusive
        Dongsheng Wang
         
        ChiCTR2000029765
        RCTtocilizumab standard of careCOVID 19 hospitalizedsome concern
        33/32 safety concern
        • statistically significant 8.6-fold increase in adverse events with a moderate degree of certainty due to some concern in risk of bias
        EMPACTA
         
        NCT04372186
        RCTtocilizumab placeboCOVID 19 hospitalizedsome concern
        259/129 conclusif
        • demonstrated 44 % decrease in death or ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
        • suggested 45 % decrease in clinical deterioration with a moderate degree of certainty due to some concern in risk of bias
        EU-CTR2020-001375-32 (PreToVid) unpublished
         
        EU-CTR2020-001375-32
        RCTtocilizumab standard of careCOVID 19 hospitalizedlow
        174/180 inconclusive
          EU-CTR2020-001748-24 (ImmCoVA) unpublished
           
          EU-CTR2020-001748-24
          RCTtocilizumab standard of careCOVID 19 hospitalizedlow
          22/27 inconclusive
            NCT04412772 (ARCHITECTS) unpublished
             
            NCT04412772
            RCTtocilizumab placeboCOVID 19 hospitalizedlow
            10/11 inconclusive
              NCT04434717 (COVITOZ-1 single dose plus two doses) unpublished
               
              NCT04434717
              RCTtocilizumab standard of careCOVID 19 hospitalizedlow
              17/9 inconclusive
                NCT04479358 (COVIDOSE-2 substudy A 120mg plus 40mg) unpublished
                 
                NCT04479358
                RCTtocilizumab standard of careCOVID 19 hospitalizedlow
                20/8 inconclusive
                  NCT04577534 (COVIDSTORM) unpublished
                   
                  NCT04577534
                  RCTtocilizumab standard of careCOVID 19 hospitalizedlow
                  26/13 inconclusive

                    COVID 19 all comers meta-analysis

                    BACC Bay Tocilizumab Trial
                     
                    NCT04356937
                    RCTtocilizumab placeboCOVID 19 all comerslow
                    161/81 inconclusive
                    • inconclusive 17 % decrease in death or ventilation (PE) with a high degree of certainty due to low risk of bias
                    TOCOVID unpublished
                     
                    NCT04332094
                    RCTtocilizumab standard of careCOVID 19 all comersNA
                    136/134 inconclusive

                      COVID-19 severe or critically meta-analysis

                      Hamed RCTtocilizumab standard of careCOVID-19 severe or criticallyhigh
                      26/23 inconclusive
                      • inconclusive 83 % increase in deaths (PE) but with a low degree of certainty due to high risk of bias
                      • inconclusive 2.2-fold increase in ICU admission (PE) but with a low degree of certainty due to high risk of bias
                      MARIPOSA
                       
                      NCT04363736
                      RCTtocilizumab tocilizumab COVID-19 severe or criticallysome concern
                      48/49 inconclusive
                        A trend for increased progression toward worse clinical status (categories 5 and 6) and death (category 7) was seen up to day 14 for the 4-mg/kg vs 8-mg/ kg group, followed by no notable difference between groups at days 21 and 28.
                        Rashad
                         
                        NCT04519385
                        RCTtocilizumab dexamethasoneCOVID-19 severe or criticallyhigh
                        74/75 safety concern
                        • statistically significant 1.2-fold increase in deaths,deaths (time to event analysis only) (PE) but with a low degree of certainty due to high risk of bias
                        • statistically significant 1.9-fold increase in death D28 but with a low degree of certainty due to high risk of bias
                        REMAP-CAP (tocilizumab)
                         
                        NCT02735707
                        RCTtocilizumab standard of careCOVID-19 severe or criticallysome concern
                        353/402 conclusif
                        • suggested 30 % decrease in deaths with a moderate degree of certainty due to some concern in risk of bias
                        • demonstrated 64 % increase in clinical improvement (PE) with a moderate degree of certainty due to some concern in risk of bias
                        Rosas (REMDACTA)
                         
                        NCT04409262
                        RCTtocilizumab placeboCOVID-19 severe or criticallysome concern
                        434/215 inconclusive
                        • inconclusive 3 % decrease in hospital discharge (PE) with a moderate degree of certainty due to some concern in risk of bias
                        Talaschian
                         
                        IRCT20081027001411N4
                        RCTtocilizumab standard of careCOVID-19 severe or criticallysome concern
                        20/20 inconclusive
                          Veiga
                           
                          NCT04403685
                          RCTtocilizumab standard of careCOVID-19 severe or criticallysome concern
                          65/64 safety concern
                          • safety concern with 1.7-fold increase in deaths,death D28 (not statistically significant)
                          • inconclusive 54 % increase in death or ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
                          CORIMUNO-TOCI-1 (Group 1)
                           
                          NCT04331808
                          RCTtocilizumab standard of careCOVID-19 severe or criticallysome concern
                          64/67 inconclusive
                            CORIMUNO-TOCI-ICU (Group 2)
                             
                            NCT04331808
                            RCTtocilizumab standard of careCOVID-19 severe or criticallysome concern
                            49/43 inconclusive
                              COVACTA (Rosas)
                               
                              NCT04320615
                              RCTtocilizumab placeboCOVID-19 severe or criticallysome concern
                              301/151 suggested
                              • inconclusive 19 % increase in clinical improvement,clinical improvement (28-day) (PE) with a moderate degree of certainty due to some concern in risk of bias
                              NCT04377750 (HMO-0224-20) unpublished
                               
                              NCT04377750
                              RCTtocilizumab placeboCOVID-19 severe or criticallyhigh
                              37/17 inconclusive
                                11 studies excluded by filtering options (0 RCT / 11 OBS)

                                PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
                                Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).