Study explorer (study characteristics and results) method abbreviations pdf   xlsx

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Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID-19 severe or critically meta-analysis

Jamaati
 
IRCT20151227025726N1
RCTdexamethasonestandard of careCOVID-19 severe or criticallysome concern
25/25 suggested
  • inconclusive 19 % increase in deaths,death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
  • inconclusive 38 % increase in mechanical ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 3.9-fold increase in radiologic improvement (14-day) with a moderate degree of certainty due to some concern in risk of bias
Munch (COVID-STEROID)
 
NCT04348305
RCTHydrocortisoneplaceboCOVID-19 severe or criticallylow
16/14 no results
    CAPE-COVID
     
    NCT02517489
    RCTHydrocortisoneplaceboCOVID-19 severe or criticallylow
    76/73 inconclusive
    • inconclusive 29 % decrease in death or ventilation (PE) with a high degree of certainty due to low risk of bias
    CODEX (Tomazini)
     
    NCT04327401
    RCTdexamethasonestandard of careCOVID-19 severe or criticallysome concern
    151/148 inconclusive
      DEXA-COVID19
       
      NCT04325061
      RCTdexamethasonestandard of careCOVID-19 severe or criticallylow
      7/12 inconclusive
        Steroids-SARI
         
        NCT04244591
        RCTmethylprednisolonestandard of careCOVID-19 severe or criticallysome concern
        24/23 inconclusive
          7 studies excluded by filtering options (4 RCT / 3 OBS)

          PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
          Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).