metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results
mNSCLC - L1 - all population metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) mNSCLC - L1 - all population
versus placebo plus SoC
	sintillimab plus SoC
	ORIENT-11, 2020 J Thorac Oncol 2020 Aug 8;S1556-0864(20)30595-5. NCT03607539	RCT	mNSCLC - L1 - all population	Sintilimab plus pemetrexed plus platine	placebo plus pemetrexed plus platine	patients with confirmed stage IIIB to IV nonsquamous NSCLC who had no previous systemic treatment for advanced and metastatic disease.	266 / 131	low	conclusif	suggested 39 % decrease in deaths (OS) demonstrated 52 % decrease in progression or deaths (PFS) (PE)
versus Standard of Care (SoC)
	cemiplimab
	EMPOWER lung1 (all population), 2021 Lancet 2021 Feb 13;397(10274):592-604. NCT03088540	RCT	mNSCLC - L1 - all population	cemiplimab	ICC	patients with confirmed stage IIIB or IIICor stage IV squamous or non-squamous non-small-celllung cancer	356 / 354	some concern	conclusif	demonstrated 32 % decrease in deaths (OS) (PE) demonstrated 41 % decrease in progression or deaths (PFS) (PE) demonstrated 1.2-fold increase in objective responses (ORR) (PE)
	durvalumab alone
	MYSTIC (D ; all population), 2020 JAMA Oncol 2020 May 1;6(5):661-674. NCT02453282	RCT	mNSCLC - L1 - all population	durvalumab	platinum-based doublet chemotherapy	first-line treatment of patients locally advanced or metastatic NSCLC with PDL1 TC >=25%	374 / 372	some concern	inconclusive	no statistically significant result
	durvalumab plus tremelimumab
	MYSTIC (DT ; all population), 2020 JAMA Oncol 2020 May 1;6(5):661-674. NCT02453282	RCT	mNSCLC - L1 - all population	durvalumab and tremelimumab	platinum-based doublet chemotherapy	first-line treatment of patients locally advanced or metastatic NSCLC with PDL1 TC >=25%	372 / 372	some concern	inconclusive	no statistically significant result
	nivolumab plus ipilimumab plus SoC
	CheckMate 9LA, 2021 Lancet Oncol 2021 Jan 18;S1470-2045(20)30641-0. ESMO Open. 2021 Oct 1 NCT03215706	RCT	mNSCLC - L1 - all population	nivo plus ipi and chemo (2 cycle)	chemotherapy platine combination	patient treated as First Line Therapy in squamous or non-squamous stage IV or recurrentNSCLC	361 / 358	some concern	conclusif	demonstrated 31 % decrease in deaths (OS) (PE) demonstrated 30 % decrease in progression or deaths (PFS) (PE) suggested 34 % decrease in deaths (OS) (extension) suggested 32 % decrease in PFS (extension) more...