metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results
mNSCLC - L1 - all population metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) mNSCLC - L1 - all population
versus placebo plus SoC
	sintillimab plus SoC
	ORIENT-11, 2020 J Thorac Oncol 2020 Aug 8;S1556-0864(20)30595-5. NCT03607539	RCT	mNSCLC - L1 - all population	Sintilimab plus pemetrexed plus platine	placebo plus pemetrexed plus platine	patients with confirmed stage IIIB to IV nonsquamous NSCLC who had no previous systemic treatment for advanced and metastatic disease.	266 / 131	low	conclusif	suggested 39 % decrease in deaths (OS) demonstrated 52 % decrease in progression or deaths (PFS) (PE)

Study

study type

Pathology

T1

T0

Patients

sample sizes

ROB

Results

RCT

mNSCLC - L1 - all population

Sintilimab plus pemetrexed plus platine

placebo plus pemetrexed plus platine

patients with confirmed stage IIIB to IV nonsquamous NSCLC who had no previous systemic treatment for advanced and metastatic disease.

266 / 131