palbociclib plus letrozoletitleabemaciclib plus endocrine therapytitlepalbociclib plus endocrine therapytitleabemaciclib plus aromatase inhibitortitleribociclib plus letrozoletitleendocrine therapytitlearomatase inhibitortitleletrozoletitleMONARCH 3, 2017 NCT02246621 la/mBC - HR-positive - 1st line (L1) 328/165MonarchE, 2021 NCT03155997 la/mBC - HR-positive - 1st line (L1) 2808/2829PENELOPE-B, 2021 NCT01864746 la/mBC - HR-positive - 1st line (L1) 628/616PALOMA-1, 2016 NCT00721409 la/mBC - HR-positive - 1st line (L1) 84/81PALOMA-2, 2016 NCT01740427 la/mBC - HR-positive - 1st line (L1) 444/222MONALEESA-2, 2016 NCT01958021 la/mBC - HR-positive - 1st line (L1) 334/334

Pathology:  la/mBC - HR-positive - 1st line (L1); 

la/mBC - HR-positive - 1st line (L1)
MONARCH 3, 2017MonarchE, 2021PENELOPE-B, 2021PALOMA-1, 2016PALOMA-2, 2016MONALEESA-2, 2016
palbociclib plus letrozole2T1T1
abemaciclib plus endocrine therapy1T1
palbociclib plus endocrine therapy1T1
abemaciclib plus aromatase inhibitor1T1
ribociclib plus letrozole1T1
endocrine therapy0T0T0
aromatase inhibitor0T0
letrozole0T0T0T0