lapatinib plus letrozoletitletrastuzumab plus endocrine therapytitlelapatinib plus fulvestranttitletrastuzumab plus chemotherapytitlefulvestranttitleletrozoletitleCALGB 40302, 2014 NCT00390455 la/mBC - HR-positive - 1st line (L1) -9/-9EGF30008 (all population), 2009 NCT00073528 la/mBC - HR-positive - 1st line (L1) 642/644EGF30008 (HER2-positive), 2009 NCT00073528 la/mBC - HR-positive - 1st line (L1) 111/108SYSUCC-002, 2022 NCT01950182 la/mBC - HR-positive - 1st line (L1) 196/196

Pathology:  la/mBC - HR-positive - 1st line (L1); 

la/mBC - HR-positive - 1st line (L1)
CALGB 40302, 2014EGF30008 (all population), 2009EGF30008 (HER2-positive), 2009SYSUCC-002, 2022
lapatinib plus letrozole2T1T1
trastuzumab plus endocrine therapy1T1
lapatinib plus fulvestrant1T1
trastuzumab plus chemotherapy0T0
fulvestrant0T0
letrozole0T0T0