All patients
adolescents (typically 12-15 years of age) adults (typically between 18 and 65yr) age >= 55 yr age >= 60 yr age >= 65 yr age >= 75 yr alpha variant (B.1.1.7, UK) any cancer autoimmune disease beta variant (B.1.351 / 501Y.V2, South Africa) children corticosteroids: no corticosteroids: yes critical disease delta variant (B.1.617.2, Indian) dialysis patients elderly (typically over 65yr) fully vaccinated gamma variant (P.1, Brazil) haematological cancers healthcare workers immunodepression invasive ventilation kidney transplant recipients no oxygen needed non invasive oxygen obese omicron variant BA.1 (B.1.1.529) omicron variant BA.2 VOC original (Wuhan) strain positive for SARS-Cov-2 at baseline severe disease solid cancer solid organ transplant recipients subjects at risk
potential COVID-19 treatments in COVID-19 (hospitalized or not) - Summary of results Outcome TE 95% CI n k I2 ROB Pub. bias death or transfer to ICUdetailed results Lee (confirmed COVID-19), 2020 1.79 [1.16; 2.76]
McKeigue (REACT-SCOT), 2020 1.44 [1.31; 1.58]
1.45 [1.33 ; 1.59 ] Lee (confirmed COVID-19), 2020, McKeigue (REACT-SCOT), 2020 2 0% 36,925 NA not evaluable deathsdetailed results Abd-Elsalam, 2020 0.99 [0.28; 3.53]
0.99 [0.28 ; 3.53 ] Abd-Elsalam, 2020 1 0% 191 NA not evaluable deaths (time to event analysis only)detailed results Manenti, 2021 0.24 [0.09; 0.65]
0.24 [0.09 ; 0.65 ] Manenti, 2021 1 0% 71 NA not evaluable hospitalization or deathdetailed results Wei, 2022 0.39 [0.26; 0.59]
0.39 [0.26 ; 0.59 ] Wei, 2022 1 0% NA not evaluable clinical improvementdetailed results Abd-Elsalam, 2020 1.08 [0.54; 2.15]
1.08 [0.54 ; 2.15 ] Abd-Elsalam, 2020 1 0% 191 NA not evaluable clinical improvement (28-day)detailed results Abd-Elsalam, 2020 1.08 [0.54; 2.15]
1.08 [0.54 ; 2.15 ] Abd-Elsalam, 2020 1 0% 191 NA not evaluable death or ventilationdetailed results Lee (confirmed COVID-19), 2020 1.63 [1.04; 2.55]
1.63 [1.04 ; 2.55 ] Lee (confirmed COVID-19), 2020 1 0% 534 NA not evaluable hospitalizationdetailed results Abu Esba LC (any NSAID use, acute and chronic), 2020 1.54 [1.06; 2.24]
Gianfransesco, 2020 0.64 [0.39; 1.06]
Lund, 2020 1.16 [0.87; 1.54]
Wei, 2022 0.39 [0.30; 0.51]
0.82 [0.42 ; 1.59 ] Abu Esba LC (any NSAID use, acute and chronic), 2020, Gianfransesco, 2020, Lund, 2020, Wei, 2022 4 94% 2,064 NA not evaluable mechanical ventilationdetailed results Abd-Elsalam, 2020 0.64 [0.18; 2.36]
0.64 [0.18 ; 2.36 ] Abd-Elsalam, 2020 1 0% 191 NA not evaluable viral clearance by day 7detailed results NCT04429711 (Biber), 2020 2.62 [1.06; 6.46]
2.62 [1.06 ; 6.46 ] NCT04429711 (Biber), 2020 1 0% 100 NA not evaluable ICU admissiondetailed results Bahl (Fully vaccinated vs unvaccinated), 2021 1.03 [0.60; 1.76]
Lund, 2020 1.04 [0.54; 2.01]
Rinott, 2020 1.42 [0.49; 4.10]
1.08 [0.73 ; 1.59 ] Bahl (Fully vaccinated vs unvaccinated), 2021, Lund, 2020, Rinott, 2020 3 0% 12,524 NA not evaluable severe COVID-19 occurrencedetailed results Abu Esba LC (any NSAID use, acute and chronic), 2020 0.73 [0.34; 1.56]
0.73 [0.34 ; 1.56 ] Abu Esba LC (any NSAID use, acute and chronic), 2020 1 0% 503 NA not evaluable 0.0 5.0 1.0 relative treatment effect www.metaEvidence.org 2024-06-11 17:11 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
pathologies: 87
- treatments: 290,547,608,830,831,829,901,680,595,828,681,1209,833,629,689,543,617,625,859,511,960,546,564,944,682,1266,943,894,560,1102,598,563,668,753,752,836,639,541,534,581,615,679,522,582,666,1149,1150,737,544,733,597,524,611,538,957,958,521,566,517,881,904,882,897,896,899,1235,898,687,740,883,947,536,591,729,887,742,878,975,570,771,888,1141,690,880,1255,567,596,1437,600,652,557,635,1236,553,628,646,645,607,395,920,1438,927,932,931,1263,599,614,942,1436,928,923,535,1046,727,818,606,954,964,962,963,1045,638,677,627,533,526,616,926,1246,726,580,568,527,588,539,585,691,1210,525,843,827,1047,1048,819,545,1253,519,619,537,514,688,529,508,656,657,832,530,512,515,754,1142,1419,513,884,632,559,889,956,684,886,631,574,509,542,1145,555,554,941,961,1250,633,676,518,532,510,528,520,955,815,893,623,622,630,593,569,516,814,649,650,589,651,968,1245,610,751,747,695,548,970,594,565,879,1257,571,626,697,572,1234,586,573,540,592,930,949,838,698,934,735,929,948,946,945,587,655,1146,531,933,613,919,725,678,921,621,959,748,1348,1256,924,1243,925,658,699,612,552,590,891,605,892,722,618,609,551,834,763,922,935,620,1317,1265,824,766,857,1291,1088,1331,1330,1329,1344,1328,1327,979,822,762,805,950,757,761,806,758,826,755,821,1288,1287,1286,760,1284,802,765,1285,759,823,804,1264,764,858,835,1262,1290,1316,1341,1342,1343,825,803,1244,523,885,734,1439
- roots T: 290
