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Sputnik V (Gam-COVID-Vac) - versus control - for COVID-19 prophylaxis (excluding children) pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

confirmed Covid-19, from 1st dose 0.27 [0.20, 0.36]< 10%1 study (1/-)100.0 %NAnot evaluable crucial-
symptomatic Covid-19 0.08 [0.05, 0.15]< 10%1 study (1/-)100.0 %NAnot evaluable important-
severe COVID-19 occurrence NaN [NaN, NaN]< 10%1 study (1/-)NaNNAnot evaluable non important-

safety endpoints 00

ATE (Myocardial infarction or ischemic stroke) 0.44 [0.10, 1.97]< 10%1 study (1/-)85.7 %NAnot evaluable non important-
intracranial hemorrhage 0.17 [0.01, 4.93]< 10%1 study (1/-)84.7 %NAnot evaluable non important-
ischemic stroke 1.32 [0.06, 29.35]< 10%1 study (1/-)43.1 %NAnot evaluable non important-
Myocardial infarction 0.66 [0.06, 7.30]< 10%1 study (1/-)63.1 %NAnot evaluable non important-
pulmonary embolism 0.33 [0.01, 16.68]< 10%1 study (1/-)70.6 %NAnot evaluable non important-
serious adverse events (SAE), any 1.10 [0.30, 4.01]< 10%1 study (1/-)44.1 %NAnot evaluable non important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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