colchicine - versus control - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths 1.02 [0.94, 1.11]< 10%4 studies (4/-)33.9 %highnot evaluable lowcrucial-
clinical deterioration 0.11 [0.01, 1.08]< 10%1 study (1/-)97.0 %some concernnot evaluable moderateimportant-
ventilation 0.17 [0.02, 1.48]< 10%1 study (1/-)94.5 %some concernnot evaluable moderateimportant-
ICU admission 1.06 [0.06, 18.45]< 10%1 study (1/-)48.4 %highnot evaluable lownon important-

LoD: level of demonstration ( demonstrated, suggested, inconclusive, safety concerns);
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.