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corticosteroids - versus control - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.98 [0.93, 1.02]< 10%6 studies (6/-)85.3 %some concernnot evaluable moderatecrucial-
death or transfer to ICU 0.68 [0.37, 1.25]< 10%1 study (1/-)89.1 %NAnot evaluable crucial-
deaths 0.87 [0.76, 0.99]< 156%12 studies (12/-)98.0 %some concernlow moderatecrucial-
deaths (time to event analysis only) 0.67 [0.35, 1.31]< 181%3 studies (3/-)87.8 %highnot evaluable lowcrucial-
clinical deterioration 0.67 [0.44, 1.03]< 10%2 studies (2/-)96.6 %some concernnot evaluable moderateimportant-
clinical improvement 1.44 [0.89, 2.33]> 165%4 studies (4/-)93.2 %highnot evaluable lowimportant-
clinical improvement (14-day) 1.18 [0.87, 1.59]> 10%3 studies (3/-)85.4 %highnot evaluable lowimportant-
clinical improvement (time to event analysis only) 1.04 [0.67, 1.62]> 10%1 study (1/-)57.5 %NAnot evaluable important-
death or ventilation 1.09 [0.71, 1.68]< 159%4 studies (4/-)34.6 %some concernnot evaluable moderateimportant-
hospital discharge 1.19 [0.86, 1.64]> 137%2 studies (2/-)85.7 %some concernnot evaluable moderateimportant-
mechanical ventilation 0.82 [0.67, 0.99]< 10%4 studies (4/-)97.8 %some concernnot evaluable moderateimportant-
radiologic improvement (14-day) 4.89 [1.15, 20.79]> 10%1 study (1/-)98.4 %NAnot evaluable important-
viral clearance 1.78 [1.06, 3.00]> 10%1 study (1/-)98.5 %NAnot evaluable important-
viral clearance (time to event analysis only) 1.78 [1.06, 3.00]> 10%1 study (1/-)98.5 %NAnot evaluable important-
ICU admission 0.88 [0.33, 2.39]< 10%2 studies (2/-)59.5 %highnot evaluable lownon important-

safety endpoints 00

serious adverse events 1.06 [0.41, 2.77]< 117%4 studies (4/-)44.9 %highnot evaluable lowimportant-
superinfection 0.91 [0.66, 1.25]< 10%2 studies (2/-)72.5 %some concernnot evaluable moderateimportant-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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