patient subgroup...
age >= 55 yr age >= 60 yr age >= 65 yr autoimmune disease corticosteroids: no corticosteroids: yes critical disease invasive ventilation no oxygen needed non invasive oxygen omicron variant BA.1 (B.1.1.529) severe disease solid organ transplant recipients subjects at risk
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
anti-inflammatoty and immuno-therapy - versus control - for COVID-19 severe or critically
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xlsx
method
abbreviations
Outcome
Relative effect 95%CI
LoD
Trt. better when
I2
k (RCT/OBS)
Bayesian probability
Overall ROB
Publication bias
Degree of certainty
Endpoint importance
Published MA
efficacy endpoints 00 death D28 0.91 [0.75, 1.10]< 1 0% 21 studies (28/-) 83.8 % some concern low moderate crucial - death or transfer to ICU 0.65 [0.35, 1.22]< 1 0% 1 study (1/-) 90.9 % NA not evaluable crucial - deaths 0.89 [0.80, 0.99]< 1 0% 37 studies (50/-) 98.7 % some concern critical moderate crucial - deaths (time to event analysis only) 1.08 [0.83, 1.39]< 1 0% 6 studies (10/-) 28.9 % some concern serious moderate crucial - clinical deterioration 0.63 [0.45, 0.88]< 1 0% 4 studies (4/-) 99.6 % some concern not evaluable moderate important - clinical improvement 1.28 [1.07, 1.53]> 1 58% 16 studies (21/-) 99.6 % some concern critical moderate important - clinical improvement (14-day) 1.77 [0.90, 3.48]> 1 67% 4 studies (7/-) 95.2 % some concern not evaluable moderate important - clinical improvement (28-day) 1.32 [0.98, 1.77]> 1 33% 9 studies (9/-) 96.8 % some concern serious moderate important - clinical improvement (7-day) 2.47 [0.37, 16.27]> 1 72% 2 studies (2/-) 82.5 % some concern not evaluable moderate important - clinical improvement (time to event analysis only) 1.15 [0.98, 1.34]> 1 41% 9 studies (10/-) 96.0 % some concern serious moderate important - death or ventilation 0.91 [0.67, 1.23]< 1 13% 4 studies (6/-) 73.2 % some concern not evaluable moderate important - hospital discharge 1.31 [0.75, 2.27]> 1 55% 3 studies (5/-) 82.9 % some concern not evaluable moderate important - mechanical ventilation 0.85 [0.64, 1.13]< 1 0% 13 studies (15/-) 86.8 % some concern low moderate important - mechanical ventilation (time to event analysis only) 0.66 [0.25, 1.72]< 1 0% 1 study (1/-) 80.2 % NA not evaluable important - radiologic improvement (14-day) 3.53 [1.19, 10.46]> 1 0% 2 studies (2/-) 98.9 % some concern not evaluable moderate important - viral clearance 6.97 [0.23, 210.35]> 1 89% 2 studies (2/-) 86.4 % some concern not evaluable moderate important - viral clearance by day 14 7.68 [0.34, 173.70]> 1 90% 2 studies (2/-) 89.7 % some concern not evaluable moderate important - ICU admission 0.58 [0.41, 0.82]< 1 0% 7 studies (8/-) 99.9 % some concern not evaluable moderate non important - off oxygenation 1.65 [0.05, 50.02]> 1 81% 2 studies (2/-) 61.1 % high not evaluable low non important - recovery 1.30 [0.64, 2.66]> 1 9% 2 studies (2/-) 76.5 % low not evaluable high non important - safety endpoints 00 related AE (TRAE) 1.26 [0.14, 11.07]< 1 0% 2 studies (2/-) 41.9 % some concern not evaluable moderate important - serious adverse events 1.07 [0.87, 1.31]< 1 30% 13 studies (16/-) 27.0 % some concern low moderate important - superinfection 0.56 [0.15, 2.02]< 1 43% 2 studies (3/-) 81.2 % low not evaluable high important - acute kidney injury 0.43 [0.14, 1.34]< 1 0% 1 study (-/1) 92.7 % NA not evaluable non important - adverse events 1.12 [0.96, 1.31]< 1 0% 11 studies (11/-) 7.8 % some concern low moderate non important - arrhythmia 0.16 [0.03, 0.90]< 1 0% 1 study (-/1) 98.1 % NA not evaluable non important - elevated liver enzymes 0.52 [0.18, 1.51]< 1 0% 1 study (-/1) 88.5 % NA not evaluable non important - Myocardial infarction 0.87 [0.19, 3.92]< 1 0% 1 study (-/1) 57.2 % NA not evaluable non important - venous thromboembolism 5.23 [0.42, 65.62]< 1 0% 1 study (-/1) 10.2 % NA not evaluable non important -
LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias;
suggested: nominally statistically significant but without a strict control of overall risk of type 1 error;
inconclusive: not nominally statistically significant;
safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies;
published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE.
Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.