Outcome |
Relative effect 95%CI |
LoD |
Trt. better when |
|
I2 |
k (RCT/OBS)
|
Bayesian probability
|
Overall ROB
|
Publication bias |
Degree of certainty |
Endpoint importance |
Published MA |
efficacy endpoints 00 |
death D28 | 0.92 [0.88, 0.97] | | < 1 | | 23% | 90 studies (104/-) | 100.0 % | some concern | critical | moderate | crucial | - |
death or transfer to ICU | 0.84 [0.62, 1.13] | | < 1 | | 53% | 5 studies (9/-) | 87.2 % | some concern | serious | moderate | crucial | - |
deaths | 0.91 [0.88, 0.95] | | < 1 | | 18% | 166 studies (219/-) | 100.0 % | some concern | critical | moderate | crucial | 1 |
deaths (time to event analysis only) | 0.88 [0.81, 0.96] | | < 1 | | 43% | 35 studies (39/-) | 99.9 % | some concern | critical | moderate | crucial | - |
clinical deterioration | 0.78 [0.66, 0.91] | | < 1 | | 48% | 34 studies (42/-) | 99.9 % | some concern | low | moderate | important | - |
clinical improvement | 1.16 [1.08, 1.24] | | > 1 | | 48% | 49 studies (58/-) | 100.0 % | some concern | critical | moderate | important | - |
clinical improvement (14-day) | 1.15 [1.00, 1.31] | | > 1 | | 47% | 26 studies (29/-) | 97.6 % | some concern | low | moderate | important | - |
clinical improvement (21-day) | 2.09 [0.04, 119.96] | | > 1 | | 0% | 1 study (1/-) | 63.7 % | NA | not evaluable | | important | - |
clinical improvement (28-day) | 1.28 [1.12, 1.46] | | > 1 | | 41% | 22 studies (22/-) | 100.0 % | some concern | critical | moderate | important | - |
clinical improvement (7-day) | 1.21 [1.02, 1.43] | | > 1 | | 53% | 17 studies (19/-) | 98.5 % | some concern | critical | moderate | important | - |
clinical improvement (time to event analysis only) | 1.16 [1.09, 1.24] | | > 1 | | 24% | 28 studies (33/-) | 100.0 % | some concern | critical | moderate | important | - |
death or ventilation | 0.92 [0.88, 0.97] | | < 1 | | 53% | 37 studies (40/-) | 99.9 % | some concern | critical | moderate | important | - |
hospital discharge | 1.03 [0.99, 1.08] | | > 1 | | 53% | 28 studies (36/-) | 94.0 % | some concern | low | moderate | important | - |
hospitalization | 1.58 [0.92, 2.70] | | < 1 | | 0% | 2 studies (4/-) | 4.8 % | some concern | not evaluable | moderate | important | - |
mechanical ventilation | 0.88 [0.81, 0.96] | | < 1 | | 25% | 54 studies (64/-) | 99.9 % | some concern | critical | moderate | important | 1 |
mechanical ventilation (time to event analysis only) | 0.79 [0.47, 1.33] | | < 1 | | 22% | 5 studies (5/-) | 81.2 % | some concern | serious | moderate | important | - |
radiologic improvement (14-day) | 2.13 [1.30, 3.50] | | > 1 | | 21% | 6 studies (6/-) | 99.9 % | some concern | not evaluable | moderate | important | - |
radiologic improvement (7-day) | 0.09 [0.01, 0.78] | | > 1 | | 0% | 2 studies (3/-) | 1.5 % | some concern | not evaluable | moderate | important | - |
Recovery (time to event analysis only) | 1.02 [0.81, 1.28] | | > 1 | | 0% | 1 study (1/-) | 56.7 % | NA | not evaluable | | important | - |
viral clearance | 1.86 [1.28, 2.69] | | > 1 | | 78% | 16 studies (23/-) | 99.9 % | some concern | critical | moderate | important | - |
viral clearance (time to event analysis only) | 1.23 [0.91, 1.66] | | > 1 | | 57% | 4 studies (9/-) | 91.3 % | some concern | not evaluable | moderate | important | - |
viral clearance by day 14 | 0.97 [0.48, 1.93] | | > 1 | | 93% | 13 studies (16/-) | 46.2 % | some concern | low | moderate | important | - |
viral clearance by day 7 | 1.09 [0.88, 1.34] | | > 1 | | 48% | 12 studies (17/-) | 78.7 % | some concern | low | moderate | important | - |
ICU admission | 0.82 [0.70, 0.95] | | < 1 | | 6% | 29 studies (35/-) | 99.5 % | some concern | critical | moderate | non important | - |
Major thrombotic events or death | 1.04 [0.80, 1.36] | | < 1 | | 0% | 1 study (1/-) | 38.7 % | NA | not evaluable | | non important | - |
off oxygenation | 0.98 [0.64, 1.51] | | > 1 | | 0% | 1 study (3/-) | 46.4 % | NA | not evaluable | | non important | - |
recovery | 1.12 [1.01, 1.23] | | > 1 | | 33% | 14 studies (14/-) | 98.6 % | some concern | critical | moderate | non important | - |
safety endpoints 00 |
AE leading to drug discontinuation | 2.43 [0.79, 7.45] | | < 1 | | 0% | 1 study (1/-) | 6.0 % | NA | not evaluable | | important | - |
cardiac arrest | 1.92 [0.35, 10.49] | | < 1 | | 0% | 1 study (1/-) | 22.7 % | NA | not evaluable | | important | - |
composite safety outcome | 1.56 [0.78, 3.11] | | < 1 | | 0% | 1 study (1/-) | 10.3 % | NA | not evaluable | | important | - |
related AE (TRAE) | 1.26 [0.14, 11.07] | | < 1 | | 0% | 2 studies (2/-) | 41.9 % | some concern | not evaluable | moderate | important | - |
related SAE (TRSAE) | 1.24 [0.50, 3.11] | | < 1 | | 0% | 1 study (1/-) | 32.0 % | NA | not evaluable | | important | - |
serious adverse events | 0.99 [0.88, 1.12] | | < 1 | | 18% | 46 studies (50/-) | 55.8 % | some concern | low | moderate | important | - |
superinfection | 0.70 [0.46, 1.07] | | < 1 | | 53% | 4 studies (5/-) | 95.0 % | low | not evaluable | high | important | - |
abnormal ECG findings | 1.50 [0.88, 2.57] | | < 1 | | 0% | 1 study (-/1) | 7.0 % | NA | not evaluable | | non important | - |
acute kidney injury | 1.18 [0.44, 3.18] | | < 1 | | 0% | 1 study (1/-) | 37.2 % | NA | not evaluable | | non important | - |
adverse events | 1.44 [1.20, 1.73] | | < 1 | | 58% | 36 studies (44/-) | 0.0 % | some concern | low | moderate | non important | - |
arrhythmia | 0.91 [0.72, 1.15] | | < 1 | | 0% | 3 studies (3/-) | 78.1 % | some concern | not evaluable | moderate | non important | - |
cardiovascular or renal events | 1.87 [1.25, 2.80] | | < 1 | | 0% | 1 study (-/1) | 0.1 % | NA | not evaluable | | non important | - |
deep vein thrombosis | 0.62 [0.23, 1.64] | | < 1 | | 0% | 2 studies (2/-) | 83.1 % | some concern | not evaluable | moderate | non important | - |
elevated liver enzymes | 0.95 [0.29, 3.10] | | < 1 | | 84% | 3 studies (3/-) | 53.6 % | some concern | not evaluable | moderate | non important | - |
hyperbilirubinemia | 0.97 [0.48, 1.93] | | < 1 | | 0% | 2 studies (2/-) | 53.8 % | low | not evaluable | high | non important | - |
long QT | 2.39 [0.24, 23.87] | | < 1 | | 80% | 2 studies (2/-) | 23.0 % | some concern | not evaluable | moderate | non important | - |
Major bleeding | 1.75 [1.14, 2.69] | | < 1 | | 0% | 4 studies (4/-) | 0.5 % | some concern | not evaluable | moderate | non important | - |
Myocardial infarction | 0.87 [0.19, 3.92] | | < 1 | | 0% | 1 study (-/1) | 57.2 % | NA | not evaluable | | non important | - |
pulmonary embolism | 0.82 [0.20, 3.29] | | < 1 | | 0% | 2 studies (2/-) | 61.1 % | some concern | not evaluable | moderate | non important | - |
renal impairment | 1.26 [0.95, 1.67] | | < 1 | | 0% | 4 studies (4/-) | 5.6 % | some concern | not evaluable | moderate | non important | - |
severe adverse events | 1.10 [0.07, 18.09] | | < 1 | | 0% | 2 studies (2/-) | 47.4 % | high | not evaluable | low | non important | - |
venous thromboembolism | 5.23 [0.42, 65.62] | | < 1 | | 0% | 1 study (-/1) | 10.2 % | NA | not evaluable | | non important | - |
AE of interest endpoints 00 |
Thromboembolic events | 0.96 [0.73, 1.27] | | < 1 | | 0% | 3 studies (3/-) | 60.5 % | some concern | not evaluable | moderate | non important | - |