studies

metastatic/advanced mGC or mGEJC, avelumab based treatment vs. non platinum-based chemotherapy, meta-analysis of study results

OutcomeTE95% CInkI2ROBPub. bias deaths (OS)detailed resultsJAVELIN Gastric 300, 2018 1.10 [0.88; 1.37] 1.10[0.88; 1.37]JAVELIN Gastric 300, 201810%371NAnot evaluable progression or deaths (PFS)detailed resultsJAVELIN Gastric 300, 2018 1.73 [1.38; 2.17] 1.73[1.38; 2.17]JAVELIN Gastric 300, 201810%371NAnot evaluable DCRdetailed resultsJAVELIN Gastric 300, 2018 0.37 [0.23; 0.60] 0.37[0.23; 0.60]JAVELIN Gastric 300, 201810%371NAnot evaluable objective responses (ORR)detailed resultsJAVELIN Gastric 300, 2018 0.49 [0.15; 1.66] 0.49[0.15; 1.66]JAVELIN Gastric 300, 201810%371NAnot evaluable TRAE (any grade)detailed resultsJAVELIN Gastric 300, 2018 0.34 [0.22; 0.52] 0.34[0.22; 0.52]JAVELIN Gastric 300, 201810%361NAnot evaluable TRAE (grade 3-4)detailed resultsJAVELIN Gastric 300, 2018 0.22 [0.12; 0.40] 0.22[0.12; 0.40]JAVELIN Gastric 300, 201810%361NAnot evaluable TRAE leading to death (grade 5)detailed resultsJAVELIN Gastric 300, 2018 0.48 [0.02; 14.39] 0.48[0.02; 14.39]JAVELIN Gastric 300, 201810%361NAnot evaluable TRAE leading to discontinuation (any grade)detailed resultsJAVELIN Gastric 300, 2018 0.74 [0.27; 2.03] 0.74[0.27; 2.03]JAVELIN Gastric 300, 201810%361NAnot evaluable Alopecia TRAE (grade 3-4)detailed resultsJAVELIN Gastric 300, 2018 0.96 [0.02; 48.74] 0.96[0.02; 48.74]JAVELIN Gastric 300, 201810%361NAnot evaluable Anaemia TRAE (grade 3-4)detailed resultsJAVELIN Gastric 300, 2018 0.04 [0.00; 0.71] 0.04[0.00; 0.71]JAVELIN Gastric 300, 201810%361NAnot evaluable Asthenia TRAE (grade 3-4)detailed resultsJAVELIN Gastric 300, 2018 0.19 [0.02; 1.63] 0.19[0.02; 1.63]JAVELIN Gastric 300, 201810%361NAnot evaluable Decreased appetite TRAE (grade 3-4)detailed resultsJAVELIN Gastric 300, 2018 0.12 [0.01; 2.25] 0.12[0.01; 2.25]JAVELIN Gastric 300, 201810%361NAnot evaluable Diarrhoea TRAE (grade 3-4)detailed resultsJAVELIN Gastric 300, 2018 0.16 [0.02; 1.31] 0.16[0.02; 1.31]JAVELIN Gastric 300, 201810%361NAnot evaluable Fatigue TRAE (grade 3-4)detailed resultsJAVELIN Gastric 300, 2018 0.48 [0.04; 5.32] 0.48[0.04; 5.32]JAVELIN Gastric 300, 201810%361NAnot evaluable Febrile neutropenia TRAE (grade 3-4)detailed resultsJAVELIN Gastric 300, 2018 0.08 [0.00; 1.40] 0.08[0.00; 1.40]JAVELIN Gastric 300, 201810%361NAnot evaluable Increase AST TRAE (grade 3-4)detailed resultsJAVELIN Gastric 300, 2018 1.29 [0.28; 5.84] 1.29[0.28; 5.84]JAVELIN Gastric 300, 201810%361NAnot evaluable Increased ALT TRAE (grade 3-4)detailed resultsJAVELIN Gastric 300, 2018 0.72 [0.16; 3.25] 0.72[0.16; 3.25]JAVELIN Gastric 300, 201810%361NAnot evaluable Increased lipase level TRAE (grade 3-4)detailed resultsJAVELIN Gastric 300, 2018 0.48 [0.04; 5.32] 0.48[0.04; 5.32]JAVELIN Gastric 300, 201810%361NAnot evaluable Infusion-related reactions TRAE (grade 3-4)detailed resultsJAVELIN Gastric 300, 2018 1.93 [0.06; 57.86] 1.93[0.06; 57.86]JAVELIN Gastric 300, 201810%361NAnot evaluable Nausea TRAE (grade 3-4)detailed resultsJAVELIN Gastric 300, 2018 0.24 [0.01; 5.32] 0.24[0.01; 5.32]JAVELIN Gastric 300, 201810%361NAnot evaluable Neutropenia TRAE (grade 3-4)detailed resultsJAVELIN Gastric 300, 2018 0.02 [0.00; 0.30] 0.02[0.00; 0.30]JAVELIN Gastric 300, 201810%361NAnot evaluable Vomiting TRAE (grade 3-4)detailed resultsJAVELIN Gastric 300, 2018 0.24 [0.01; 5.32] 0.24[0.01; 5.32]JAVELIN Gastric 300, 201810%361NAnot evaluable Weight decreased TRAE (grade 3-4)detailed resultsJAVELIN Gastric 300, 2018 0.07 [0.00; 1.17] 0.07[0.00; 1.17]JAVELIN Gastric 300, 201810%361NAnot evaluable0.05.01.0relative treatment effectwww.metaEvidence.org2024-11-01 00:20 +01:00

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;

pathologies: 273,122,271,262,260,219,184,272,123,187,185,186,304 - treatments: 852,417,603,1051,876