studies

breast cancer - HR positive, ribociclib based treatment vs. all, meta-analysis of study results

OutcomeTE95% CInkI2ROBPub. bias deaths (OS)detailed resultsMONALEESA-2, 2016 0.76 [0.63; 0.92] MONALEESA-3, 2018 0.72 [0.57; 0.91] 0.74[0.64; 0.87]MONALEESA-2, 2016, MONALEESA-3, 201820%1,394lownot evaluable deaths (OS) (extension)detailed resultsMONALEESA-3, 2018 0.73 [0.59; 0.90] 0.73[0.59; 0.90]MONALEESA-3, 201810%726NAnot evaluable progression or deaths (PFS)detailed resultsMONALEESA-2, 2016 0.56 [0.43; 0.72] MONALEESA-3, 2018 0.59 [0.48; 0.73] MONALEESA-7, 2018 0.55 [0.44; 0.69] 0.57[0.50; 0.65]MONALEESA-2, 2016, MONALEESA-3, 2018, MONALEESA-7, 201830%2,066lownot evaluable CBRdetailed resultsMONALEESA-2, 2016 1.46 [1.02; 2.10] MONALEESA-3, 2018 1.40 [1.01; 1.94] MONALEESA-7, 2018 1.64 [1.16; 2.33] 1.49[1.22; 1.82]MONALEESA-2, 2016, MONALEESA-3, 2018, MONALEESA-7, 201830%2,066lownot evaluable objective responses (ORR)detailed resultsMONALEESA-2, 2016 1.81 [1.31; 2.50] MONALEESA-3, 2018 1.75 [1.22; 2.52] MONALEESA-7, 2018 1.64 [1.19; 2.26] 1.73[1.43; 2.10]MONALEESA-2, 2016, MONALEESA-3, 2018, MONALEESA-7, 201830%2,066lownot evaluable0.25.01.0relative treatment effectwww.metaEvidence.org2024-05-23 15:13 +02:00

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;

pathologies: 4,319,144,356,351,357,352,354,353,358,359 - treatments: 1379,1403,1381,1380

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