• metastatic/advanced mGC or mGEJC
• mGC or mGEJC - 1st line (L1)
• mGC or mGEJC - L1 - all population
• mGC or mGEJC - L1 - HER2 neg/PDL1 positive 2
• mGC or mGEJC - L1 - HER2 negative 1
• mGC or mGEJC - L1 - HER2 positive
• mGC or mGEJC - L1 - PDL1 positive 4
• mGC or mGEJC - 2nd Line (L2)
• mGC or mGEJC - L2 - all population 4
• mGC or mGEJC - L2 - PDL1 positive 1
• mGC or mGEJC - maintenance (M)
• mGC or mGEJC - M - HER2 negative 1
• mGC or mGEJC - M - HER2 neg/PDL1 positive 1
• gene alteration defined cancer

 

• gene alteration target therapy
• KRAS gene alteration targeted therapy
• sotorasib
• NTRK gene alteration targeted therapy
• larotrectinib
• RET gene alteration targeted therapy
• pralsetinib
• selpercatinib

• versus all
• vs non active control
• vs no control (uncontrolled study)

  All patients

• study list
• mapping
• overview
• meta-analysis
• forest plot
• NMA
• excluded

Top evidence (RCT only, high risk of bias excluded) Best available evidence (possibly low or very low) All RCTs All studies (RCT+OBS)   studies

gene alteration defined cancer, gene alteration target therapy vs. all, meta-analysis of study results

No data for this selection

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;