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mNSCLC - L1 - PDL1 positive, Immune checkpoint association , meta-analysis of study results

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths (OS) 0.90 [0.73, 1.10]< 150%3 studies (3/-)85.6 %some concernnot evaluable moderatecrucial-
progression or deaths (PFS) 0.95 [0.78, 1.14]< 150%3 studies (3/-)71.7 %some concernnot evaluable moderateimportant-
objective responses (ORR) 1.08 [0.86, 1.37]> 124%3 studies (3/-)75.5 %some concernnot evaluable moderatenon important-

safety endpoints 00

AE (any grade) 0.43 [0.15, 1.24]< 10%1 study (1/-)94.2 %NAnot evaluable non important-
AE (grade 3-4) 0.86 [0.56, 1.35]< 10%1 study (1/-)74.0 %NAnot evaluable non important-
AE leading to death (grade 5) 3.45 [1.24, 9.59]< 10%1 study (1/-)0.9 %NAnot evaluable non important-
AE leading to treatment discontinuation (any grade) 1.63 [0.91, 2.93]< 10%1 study (1/-)5.2 %NAnot evaluable non important-
SAE (any grade) 1.93 [1.22, 3.04]< 10%1 study (1/-)0.2 %NAnot evaluable non important-
STRAE (any grade) 1.50 [0.82, 2.75]< 169%2 studies (2/-)9.6 %some concernnot evaluable moderatenon important-
STRAE (grade 3-4) 1.98 [1.32, 2.98]< 10%1 study (1/-)0.0 %NAnot evaluable non important-
TRAE (any grade) 0.34 [0.09, 1.30]< 193%2 studies (2/-)94.3 %some concernnot evaluable moderatenon important-
TRAE (grade 3-4) 0.60 [0.23, 1.58]< 191%2 studies (2/-)84.9 %some concernnot evaluable moderatenon important-
TRAE leading to death (grade 5) 0.98 [0.31, 3.06]< 10%2 studies (2/-)51.3 %some concernnot evaluable moderatenon important-
TRAE leading to discontinuation (any grade) 1.85 [0.63, 5.45]< 186%2 studies (2/-)13.1 %some concernnot evaluable moderatenon important-
TRAE leading to discontinuation (grade 3-4) 5.13 [2.63, 10.00]< 10%1 study (1/-)0.0 %NAnot evaluable non important-

TRAE (grade 3-4) endpoints 00

Anaemia TRAE (grade 3-4) 0.11 [0.04, 0.28]< 10%1 study (1/-)100.0 %NAnot evaluable non important-
Asthenia TRAE (grade 3-4) 1.24 [0.33, 4.65]< 10%1 study (1/-)37.5 %NAnot evaluable non important-
Constipation TRAE (grade 3-4) 0.99 [0.02, 50.01]< 10%1 study (1/-)50.2 %NAnot evaluable non important-
Decreased appetite TRAE (grade 3-4) 0.99 [0.25, 3.99]< 10%1 study (1/-)50.6 %NAnot evaluable non important-
Diarrhoea TRAE (grade 3-4) 3.00 [0.60, 14.96]< 10%1 study (1/-)9.1 %NAnot evaluable non important-
Fatigue TRAE (grade 3-4) 2.00 [0.60, 6.70]< 10%1 study (1/-)13.1 %NAnot evaluable non important-
Nausea TRAE (grade 3-4) 0.28 [0.06, 1.35]< 10%1 study (1/-)94.3 %NAnot evaluable non important-
Neutropenia TRAE (grade 3-4) 0.01 [0.00, 0.23]< 10%1 study (1/-)99.9 %NAnot evaluable non important-
Pruritus TRAE (grade 3-4) 3.97 [0.18, 88.42]< 10%1 study (1/-)19.5 %NAnot evaluable non important-
Rash TRAE (grade 3-4) 18.21 [1.05, 315.26]< 10%1 study (1/-)2.4 %NAnot evaluable non important-
Vomiting TRAE (grade 3-4) 0.10 [0.01, 0.76]< 10%1 study (1/-)98.6 %NAnot evaluable non important-

AE (grade 3-4) endpoints 00

Anaemia AE (grade 3-4) 1.14 [0.41, 3.20]< 10%1 study (1/-)40.0 %NAnot evaluable non important-
Arthralgia AE (grade 3-4) 2.01 [0.36, 11.05]< 10%1 study (1/-)21.3 %NAnot evaluable non important-
Asthenia AE (grade 3-4) 0.25 [0.03, 2.22]< 10%1 study (1/-)89.3 %NAnot evaluable non important-
Back pain AE (grade 3-4) 0.50 [0.04, 5.51]< 10%1 study (1/-)71.4 %NAnot evaluable non important-
Constipation AE (grade 3-4) 1.00 [0.14, 7.12]< 10%1 study (1/-)50.1 %NAnot evaluable non important-
Cough AE (grade 3-4) 0.50 [0.02, 14.89]< 10%1 study (1/-)65.4 %NAnot evaluable non important-
Decreased appetite AE (grade 3-4) 6.03 [0.30, 120.98]< 10%1 study (1/-)12.3 %NAnot evaluable non important-
Diarrhoea AE (grade 3-4) 10.29 [1.31, 80.96]< 10%1 study (1/-)1.4 %NAnot evaluable non important-
Dyspnoea AE (grade 3-4) 0.87 [0.31, 2.43]< 10%1 study (1/-)60.6 %NAnot evaluable non important-
Fatigue AE (grade 3-4) 1.51 [0.42, 5.39]< 10%1 study (1/-)26.5 %NAnot evaluable non important-
Hypothyroidism AE (grade 3-4) 1.00 [0.06, 16.01]< 10%1 study (1/-)50.1 %NAnot evaluable non important-
Increase AST AE (grade 3-4) 2.52 [0.48, 13.09]< 10%1 study (1/-)13.7 %NAnot evaluable non important-
Increased ALT AE (grade 3-4) 2.28 [0.69, 7.50]< 10%1 study (1/-)8.7 %NAnot evaluable non important-
Nausea AE (grade 3-4) 4.01 [0.18, 89.26]< 10%1 study (1/-)19.3 %NAnot evaluable non important-
Pneumonia AE (grade 3-4) 1.36 [0.72, 2.56]< 10%1 study (1/-)17.2 %NAnot evaluable non important-
Pneumonitis AE (grade 3-4) 2.21 [0.83, 5.91]< 10%1 study (1/-)5.6 %NAnot evaluable non important-
Pruritus AE (grade 3-4) 0.50 [0.04, 5.51]< 10%1 study (1/-)71.4 %NAnot evaluable non important-
Pyrexia AE (grade 3-4) 6.03 [0.30, 120.98]< 10%1 study (1/-)12.3 %NAnot evaluable non important-
Rash AE (grade 3-4) 16.38 [0.94, 286.59]< 10%1 study (1/-)2.9 %NAnot evaluable non important-
Vomiting AE (grade 3-4) 4.03 [0.45, 36.27]< 10%1 study (1/-)10.8 %NAnot evaluable non important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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