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mNSCLC - L1 - PDL1 positive, durvalumab based treatment , meta-analysis of study results

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths (OS) 0.76 [0.56, 1.03]< 10%1 study (1/-)96.4 %NAnot evaluable crucial-
progression or deaths (PFS) 0.87 [0.59, 1.29]< 10%1 study (1/-)75.7 %NAnot evaluable important-
objective responses (ORR) 0.91 [0.58, 1.43]> 10%1 study (1/-)34.2 %NAnot evaluable non important-

safety endpoints 00

AE (any grade) 0.42 [0.14, 1.22]< 10%1 study (1/-)94.4 %NAnot evaluable non important-
AE (grade 3-4) 0.91 [0.58, 1.41]< 10%1 study (1/-)66.7 %NAnot evaluable non important-
AE leading to death (grade 5) 0.75 [0.20, 2.86]< 10%1 study (1/-)66.0 %NAnot evaluable non important-
AE leading to treatment discontinuation (any grade) 0.75 [0.38, 1.46]< 10%1 study (1/-)80.2 %NAnot evaluable non important-
SAE (any grade) 1.22 [0.77, 1.94]< 10%1 study (1/-)20.0 %NAnot evaluable non important-
STRAE (any grade) 0.38 [0.18, 0.77]< 10%1 study (1/-)99.6 %NAnot evaluable non important-
TRAE (any grade) 0.21 [0.12, 0.38]< 10%1 study (1/-)100.0 %NAnot evaluable non important-
TRAE (grade 3-4) 0.36 [0.22, 0.61]< 10%1 study (1/-)100.0 %NAnot evaluable non important-
TRAE leading to death (grade 5) 0.95 [0.06, 15.32]< 10%1 study (1/-)51.4 %NAnot evaluable non important-
TRAE leading to discontinuation (any grade) 0.47 [0.21, 1.04]< 10%1 study (1/-)96.9 %NAnot evaluable non important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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