Study Exclusion reasons Remarks Reference(s)
Rimland, 2020 single-arm  
Ahn, 2020 -

Ahn J. Korean Med. Sci. 2020; 35:e149 10.3346/jkms.2020.35.e149

 
Shen, 2020 -

Shen C JAMA 2020 Mar 27;323(16):1582-1589. 10.1001/jama.2020.4783

 
BREATH-19 Study, 0 single-arm  
Kragholm, 2020 population based cohort retrospective

Kragholm K et al. Clinical and Translational Science 10.1111/cts.12904

 
O'Brien (Part A: uninfected household contacts), 2021 randomized controlled trial < Study carried out before the release of the omicron variant >

O'Brien MP et al. medrxiv;2021.06.14.21258569v1 10.1101/2021.06.14.21258569

O'Brien MP et al. New England Journal of Medicine 10.1056/NEJMoa2109682

O?Brien MP et al. medRxiv 10.1101/2021.06.14.21258567

 
O'Brien (Part B: recently infected asymptomatic patients), 2021 randomized controlled trial

O'Brien MP et al. medrxiv;2021.06.14.21258569v1 10.1101/2021.06.14.21258569

 
Gritti et al., 2020 single-arm inadequate or absent control group

Gritti et al. medRxiv 10.1101/2020.04.01.20048561

 
Huijie Bian, 2020 non randomized controlled trial not relevant study design study with major methological limitations precluding any conclusion

Huijie Bian medRxiv 10.1101/2020.03.21.20040691

 
Yin Wang et al., 2020 retrospective cohort (registry) not relevant study design

Yin Wang et al. medRxiv 10.1101/2020.03.06.20032342

 
Ye, 2020 - no control group

Ye J. Med. Virol. 2020; : 10.1002/jmv.25882

 
Zhang, 2020 - no control group

Zhang Chest 2020; : 10.1016/j.chest.2020.03.039

 
Zhang, 2020 - no control group

Zhang L Aging (Albany NY) 2020 Apr 22;12(8):6536-6542. 10.18632/aging.103102

 
Toniati, 2020 observational study no control group

Toniati Autoimmun Rev 2020; 19:102568 10.1016/j.autrev.2020.102568

 
Price, 2020 retrospective cohort no control group

Price Chest 2020; : 10.1016/j.chest.2020.06.006

 
Roschewski, 2020 observational study no control group

Roschewski M Sci Immunol 2020 Jun 5;5(48):eabd0110. 10.1126/sciimmunol.abd0110

 
CT-P59 1.2, 2020 randomized controlled trial no clinically relevant endpoint preliminary unpublished results extracted from the EMA review document. < Study carried out before the release of the omicron variant >  
Yildiz, 2021 randomized controlled trial no clinically relevant endpoint

Yildiz E Indian J Otolaryngol Head Neck Surg 2021 Jul 10;1-6. 10.1007/s12070-021-02749-9

 
Bargay-Lleonart, 2022 randomized controlled trial no clinically relevant endpoint The trial was terminated early due to the impossibility of recruitment due to the pandemic.

Bargay-Lleonart J J Clin Med 2022 May 27;11(11):3039. 10.3390/jcm11113039

 
Dai W, 2020 retrospective cohort other inadequate statistical analysis

Wei Dai, Jian Wu, Tianfu Li, Jiawei Shen, Rongrong Pang, Bangshun He, Tao Luo, Yanju Guo, Yang Yang, Jun Zhao, Mingchao Zhang, Na Li, Ying Han, Qiuyue Wu, Weiwei Li, Xinyi Xia BMC Cardiovascular Diabetology

 
Bernaola, 2020 retrospective cohort other

Nikolas Bernaola medrxiv;2020.07.17.20155960v1 10.1101/2020.07.17.20155960

 
Holt, 2020 retrospective cohort other no CI reported

Holt, Gregory E 10.21203/rs.3.rs-39875/v1

 
Klopfenstein, 2020 retrospective cohort other major flaws in the method

Klopfenstein T International Journal of Infectious Diseases 10.1016/j.ijid.2020.08.024

 
Cantini, 2020 non randomized controlled trial other same patients than in Cantini et al. (octobre publication)

Cantini F J Infect 2020 Aug;81(2):318-356. 10.1016/j.jinf.2020.04.017

 
Isa, 2021 randomized controlled trial other Phase I: multiple-dose administration of REGEN-COV.

Isa F et al. medRxiv 10.1101/2021.11.10.21265889