• AKT inhibitor
• capivasertib based treatment
• capivasertib plus paclitaxel
• ipatasertib based treatment
• ipatasertib plus paclitaxel
• antibody–drug conjugate
• trastuzumab emtansine
• trastuzumab emtasine plus endocrine therapy
• aurora kinase inhibitors
• alisertib plus paclitaxel
• biguanide
• metformin
• celecoxib plus endocrine therapy
• cyclin inhibitor
• abemaciclib based treatment
• abemaciclib plus aromatase inhibitor
• abemaciclib plus endocrine therapy
• abemaciclib plus fulvestrant
• dalpiciclib plus fulvestrant
• palbociclib based treatment
• palbociclib plus endocrine therapy
• palbociclib plus fulvestrant
• palbociclib plus letrozole
• ribociclib based treatment
• ribociclib plus endocrine therapy
• ribociclib plus fulvestrant
• ribociclib plus letrozole
• HDAC inhibitor
• entinostat plus exemestane
• tucidinostat based treatment
• tucidinostat plus exemestane
• HER inhibitor
• HER2 inhibitor
• trastuzumab based treatment
• trastuzumab plus endocrine therapy
• TKI anti HER1/EGFR and HER2/neu
• lapatinib based treatment
• lapatinib plus fulvestrant
• lapatinib plus letrozole
• IGF-1R inhibitors
• dalotuzumab plus ridaforolimus plus exemestane
• ganitumab plus endocrine therapy
• Immunostimulant
• vaccine
• OBI-822/OBI-821 plus cyclophosphamide
• mTOR inhibitors
• sapanisertib plus fulvestrant
• phosphoinositide 3-kinase (PI3K) inhibitor
• alpelisib based treatment
• alpelisib plus fulvestrant
• alpelisib plus letrozole
• buparlisib based treatment
• buparlisib plus fulvestrant
• buparlisib plus letrozole
• taselisib based treatment
• taselisib plus letrozole
• VEGF(R) inhibitor
• cediranib plus fulvestrant

• versus all
• vs chemotherapy
• vs non platinum-based chemotherapy
• vs nucleoside analogues (pyrimidine/purine)
• vs capecitabine
• vs taxanes
• vs paclitaxel
• vs endocrine therapy
• vs aromatase inhibitor
• vs exemestane
• vs exemestane plus ridaforolimus
• vs fulvestrant
• vs letrozole
• vs HER inhibitor
• vs HER2 inhibitor
• vs trastuzumab based treatment
• vs trastuzumab plus chemotherapy
• vs trastuzumab plus endocrine therapy
• vs non active control
• vs placebo

  Top evidence (RCT only, high risk of bias excluded) Best available evidence (possibly low or very low) All RCTs All studies (RCT+OBS)

• study list
• mapping
• overview
• meta-analysis
• forest plot
• NMA
• excluded

color = results color = ROB demonstrated suggested inconclusive safety concern ongoing study not assessable low moderate serious ongoing study display ongoing demontrated benefit only