hydroxychloroquine versus control in COVID 19 hospitalized

death or ventilation

Study Studied vs control treatments Type Study endpoint Relative effect (95%CI) x1/n1 x0/n0 Study risk of bias Indirectness Remarks Tags
Gonzalez (HCQ), 2020 NCT04391127 hydroxychloroquine vs placebo RCT Respiratory deterioration or death 0.69 [0.22;2.21] C 6/33   9/37 some concern
 -
HYCOVID, 2020 NCT04325893 hydroxychloroquine vs placebo RCT death or ventilation 1.12 [0.45;2.80] -/124   -/123 some concern
 -
ORCHID, 2020 NCT04332991 hydroxychloroquine vs placebo RCT Composite of death or ECMO through 28 day 1.13 [0.60;2.14] -/241   -/236 low
 -
RECOVERY, 2020 NCT04381936 hydroxychloroquine vs standard of care RCT Invasive mechanical ventilation or death 1.14 [1.03;1.27] -/1300   -/2623 some concern
 -
SOLIDARITY (WHO study) HCQ, 2020 NCT04315948 hydroxychloroquine vs standard of care RCT death or initiation of ventilation 1.11 [0.87;1.42] -/947   -/906 some concern
 - 400mg
Meta-analysis 1.13 [1.03; 1.24]
I2 = 0 % 		-/2645   -/3925 some concern no overall indirectness k=5 studies; N=6,570 patients overall
x1: number of event in experimental group (studied treatment); n1: sample size of experimental group; x0: number of event in control group (control treatment); n0: sample size of control group;
Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s);
Conclusive (statistically conclusive): statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias;

Forest plot

hydroxychloroquine in COVID 19 hospitalized
death or ventilation StudyTE95% CInROB Gonzalez, 2020 1 Gonzalez (HCQ), 2020 Respiratory deterioration or death 0.69[0.22; 2.21]70some concern HYCOVID, 2020HYCOVID, 2020 death or ventilation 1.12[0.45; 2.80]247some concern ORCHID, 2020ORCHID, 2020 Composite of death or ECMO through 28 day 1.13[0.60; 2.14]477low RECOVERY, 2020RECOVERY, 2020 Invasive mechanical ventilation or death 1.14[1.03; 1.27]3923some concern SOLIDARITY, 2020 2 SOLIDARITY (WHO study) HCQ, 2020 death or initiation of ventilation 1.11[0.87; 1.42]1853some concern Total I2 = 0% 1.13[1.03; 1.24]6570some concern0.22.01.0studied trt. betterrelative treatment effectwww.metaEvidence.org2024-05-03 11:02 +02:00

1: HCQ; 2: WHO study) HC;

Sensitivity analysis

SubsetOR95% CInkI2ROB vs placebotitle aaa 1.04[0.64; 1.67]7940%low3 Gonzalez (HCQ), 2020, HYCOVID, 2020, ORCHID, 2020 vs standard of caretitle aaa 1.14[1.03; 1.25]5,7760%moderate2 RECOVERY, 2020, SOLIDARITY (WHO study) HCQ, 2020 COVID 19 hospitalizedtitle aaa 1.13[1.03; 1.24]6,5700%moderate5 Gonzalez (HCQ), 2020, HYCOVID, 2020, ORCHID, 2020, RECOVERY, 2020, SOLIDARITY (WHO study) HCQ, 2020 randomized trialstitle aaa 1.13[1.03; 1.24]6,5700%moderate5 Gonzalez (HCQ), 2020, HYCOVID, 2020, ORCHID, 2020, RECOVERY, 2020, SOLIDARITY (WHO study) HCQ, 2020 observational studiestitle aaa -----0 low risk of biastitle aaa 1.13[1.03; 1.24]6,5700%moderate5 Gonzalez (HCQ), 2020, HYCOVID, 2020, ORCHID, 2020, RECOVERY, 2020, SOLIDARITY (WHO study) HCQ, 2020 high risk of biastitle aaa -----0 all studiestitle aaa 1.13[1.03; 1.24]6,5700%moderate5 Gonzalez (HCQ), 2020, HYCOVID, 2020, ORCHID, 2020, RECOVERY, 2020, SOLIDARITY (WHO study) HCQ, 20200.510.01.0

Bayesian posterior probability of treatment effect

1.0relative treatment effect (TE)studied trt. better0.020.01 %Risk of biaslowsome concernshigh

Bayesian (posterior) relative TE 95% CI: 1.13 [1.03; 1.24]

posterior probability of favorable treatment effect (PTE): 0.5 %

some concern risk of bias. This probability should be interpreted according to the risk of bias.

Publication bias, Funnel plot

funnel plot

0.0-1.41.50.7100.000Gonzalez (HCQ), 2020HYCOVID, 2020ORCHID, 2020RECOVERY, 2020SOLIDARITY (WHO study) HCQ, 2020

Asymetry test p-value = 0.2306 (by Egger's regression)

p values plot

0.01.00.01.0

treatments: 657,832, outcome: 441, pathologies: 95,94,90,91, subgroup: 0, T0: 649,650,589,651,968