• locally advanced (laHNSCC)
• laHNSCC - (neo)adjuvant (NA)
• laHNSCC - 1st line (L1) 1
• laHNSCC - 2nd line (L2)

 

• immune chekpoint inhibitors
• anti-PD-(L)1
• avelumab based treatment
• avelumab alone

• versus all
• vs non active control
• vs placebo

• study list
• mapping
• overview
• meta-analysis
• forest plot
• NMA
• excluded

Top evidence (RCT only, high risk of bias excluded) Best available evidence (possibly low or very low) All RCTs All studies (RCT+OBS)

Comparator:  vs placebo; 
Risk of bias:  low;   some concerns;   high;  NA;