All patients
Age < 65y (younger) Age > 65y ECOG 0 ECOG 1 Gender, female Gender, male Hemoglobin concentration < 10g/dl hemoglobin concentration > 10g/dl metastasis (liver ) metastasis (lymph node ) metastasis (visceral) smoker (Current) smoker (Former) smoker (never)
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
mUC - L1 - PDL1 positive, immune chekpoint inhibitors vs. all, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results DANUBE (D vs C - PDL1>25%), 2020 0.89 [0.71; 1.11]
DANUBE (DT vs C - PDL1>25%), 2020 0.74 [0.59; 0.93]
0.81 [0.68 ; 0.97 ] DANUBE (D vs C - PDL1>25%), 2020, DANUBE (DT vs C - PDL1>25%), 2020 2 22% 828 moderate not evaluable progression or deaths (PFS)detailed results DANUBE (D vs C - PDL1>25%), 2020 1.24 [0.74; 2.08]
DANUBE (DT vs C - PDL1>25%), 2020 1.02 [0.62; 1.68]
1.12 [0.78 ; 1.61 ] DANUBE (D vs C - PDL1>25%), 2020, DANUBE (DT vs C - PDL1>25%), 2020 2 0% 828 moderate not evaluable DORdetailed results DANUBE (D vs C - PDL1>25%), 2020 0.27 [0.13; 0.57]
DANUBE (DT vs C - PDL1>25%), 2020 0.38 [0.19; 0.75]
0.33 [0.20 ; 0.54 ] DANUBE (D vs C - PDL1>25%), 2020, DANUBE (DT vs C - PDL1>25%), 2020 2 0% 354 moderate not evaluable objective responses (ORR)detailed results DANUBE (D vs C - PDL1>25%), 2020 0.41 [0.27; 0.62]
DANUBE (DT vs C - PDL1>25%), 2020 0.94 [0.64; 1.39]
0.62 [0.28 ; 1.41 ] DANUBE (D vs C - PDL1>25%), 2020, DANUBE (DT vs C - PDL1>25%), 2020 2 88% 828 moderate not evaluable 0.2 2.0 1.0 relative treatment effect www.metaEvidence.org 2024-06-02 17:52 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 157
- treatments: 204,504,850,329,558,579,549,868,502,741,556,812,813,367,851,361,602,1070,671,865,744,696,1083,1281,1282,1283,1082,866,852,417,603,1051,876,853,1018,661,673,1049,1440,854,374,1073,953,672,1080,862,855,360,719,721,720,842,642,674,1085,863,503,847,982,359,575,577,576,869,1081,981,875,505,952,1021,1079,767,1071,1074,873,561,644,1251,1044,724,874,1043,1041,1042,940,1258,746,745,856,634,861,416,864,769,980,369,743