studies

mBC - TNBC - L1 - PDL1 positive, immune chekpoint inhibitors vs. all, meta-analysis of study results

OutcomeTE95% CInkI2ROBPub. bias deaths (OS)detailed resultsIMpassion-130 (PDL1>1%), 2018 0.71 [0.54; 0.94] KEYNOTE-355 (CPS>1), 2020 0.86 [0.72; 1.03] KEYNOTE-355 (CPS>10), 2020 0.73 [0.56; 0.96] 0.79[0.69; 0.90]IMpassion-130 (PDL1>1%), 2018, KEYNOTE-355 (CPS>1), 2020, KEYNOTE-355 (CPS>10), 202030%1,328lownot evaluable PFS (extension)detailed resultsIMpassion-130 (PDL1>1%), 2018 0.63 [0.50; 0.80] 0.63[0.50; 0.80]IMpassion-130 (PDL1>1%), 201810%369NAnot evaluable progression or deaths (PFS)detailed resultsIMpassion-130 (PDL1>1%), 2018 0.62 [0.49; 0.78] KEYNOTE-355 (CPS>1), 2020 0.75 [0.62; 0.91] KEYNOTE-355 (CPS>10), 2020 0.66 [0.50; 0.88] 0.69[0.60; 0.78]IMpassion-130 (PDL1>1%), 2018, KEYNOTE-355 (CPS>1), 2020, KEYNOTE-355 (CPS>10), 202030%1,328lownot evaluable DORdetailed resultsIMpassion-130 (PDL1>1%), 2018 0.60 [0.42; 0.85] 0.60[0.42; 0.85]IMpassion-130 (PDL1>1%), 201810%369NAnot evaluable objective responses (ORR)detailed resultsIMpassion-130 (PDL1>1%), 2018 1.96 [1.29; 2.98] KEYNOTE-355 (CPS>1), 2020 1.28 [0.92; 1.80] KEYNOTE-355 (CPS>10), 2020 1.62 [1.01; 2.60] 1.55[1.20; 2.00]IMpassion-130 (PDL1>1%), 2018, KEYNOTE-355 (CPS>1), 2020, KEYNOTE-355 (CPS>10), 2020318%1,328lownot evaluable0.25.01.0relative treatment effectwww.metaEvidence.org2024-06-01 07:20 +02:00

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;

pathologies: 143 - treatments: 204,504,850,329,558,579,549,868,502,741,556,812,813,367,851,361,602,1070,671,865,744,696,1083,1281,1282,1283,1082,866,852,417,603,1051,876,853,1018,661,673,1049,1440,854,374,1073,953,672,1080,862,855,360,719,721,720,842,642,674,1085,863,503,847,982,359,575,577,576,869,1081,981,875,505,952,1021,1079,767,1071,1074,873,561,644,1251,1044,724,874,1043,1041,1042,940,1258,746,745,856,634,861,416,864,769,980,369,743